Screening for Peripheral Arterial Disease

Marcoux, Rita M.; Larrat, E. Paul; Taubman, Albert H.; Wilson, John

doi:10.1016/s1086-5802(16)30076-6

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…It has been estimated that over 2 million individuals with IC have a reduced quality of life, particularly relating to limitations in ambulation. 10,112 It is important for healthcare providers to evaluate the burden of the disease which ultimately will guide selection of appropriate treatments for improving the HRQOL of PAD patients. Thus, questionnaires that are simple, accurate and effective for determining perceived quality of life and functional status in patients with IC have utility in clinical as well as research settings.…”

Section: Discussionmentioning

confidence: 99%

Assessment of functional status and quality of life in claudication

Mays

Casserly

Kohrt

et al. 2011

Journal of Vascular Surgery

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Background Treadmill walking is commonly used to evaluate walking impairment and efficacy of treatment for intermittent claudication (IC) in clinical and research settings. Although this is an important measure, it does not provide information about how patients perceive the effects of their treatments on more global measures of health-related quality of life (HRQOL). Methods PubMed/Medline was searched to find publications about the most commonly used questionnaires to assess functional status and/or general and disease-specific HRQOL in patients with PAD who experience IC. Inclusion criteria for questionnaires were based on existence of a body of literature in symptomatic PAD. Results Six general questionnaires and 7 disease-specific questionnaires are included with details about the number of domains covered and how each tool is scored. The Medical Outcomes Study Short Form 36 item questionnaire and Walking Impairment Questionnaire are currently the most used general and disease-specific questionnaires at baseline and following treatment for IC, respectively. Conclusions The use of tools which assess functional status and HRQOL has importance in both the clinical and research areas to assess treatment efficacy from the patient perspective. Therefore, assessing HRQOL in addition to treadmill-measured walking ability provides insight as to effects of treatments on patient outcomes and may help guide therapy.

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Section: Discussionmentioning

confidence: 99%

Assessment of functional status and quality of life in claudication

Mays

Casserly

Kohrt

et al. 2011

Journal of Vascular Surgery

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“…It is estimated that PAOD affects and reduces the quality of life in about 2 million Americans. Furthermore, millions of Americans also suffer from PAOD-associated impairment of activity of daily living (ADL) and quality of life (QOL) (Marcoux et al, 1996;Hirsch et al, 2001;Golomb et al, 2006). The morbidity and mortality are relatively high because effective treatments are unavailable.…”

Section: Effects Of Scs On Peripheral Vascular System In the Lower LImentioning

confidence: 99%

Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: A review of experimental studies

Linderoth

Foreman

2008

Autonomic Neuroscience

156

106

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Spinal cord stimulation (SCS) is a widely used clinical technique to treat ischemic pain in peripheral, cardiac and cerebral vascular diseases. The use of this treatment advanced rapidly during the late 80's and 90's, particularly in Europe. Although the clinical benefits of SCS are clear and the success rate remains high, the mechanisms are not yet completely understood. SCS at lumbar spinal segments (L2-L3) produces vasodilation in the lower limbs and feet which is mediated by antidromic activation of sensory fibers and decreased sympathetic outflow. SCS at thoracic spinal segments (T1-T2) induces several benefits including pain relief, reduction in both frequency and severity of angina attacks, and reduced short-acting nitrate intake. The benefits to the heart are not likely due to an increase, or redistribution of local blood flow, rather, they are associated with SCS-induced myocardial protection and normalization of the intrinsic cardiac nervous system. At somewhat lower cervical levels (C3-C6), SCS induces increased blood flow in the upper extremities. SCS at the upper cervical spinal segments (C1-C2) increased cerebral blood flow, which is associated with a decrease in sympathetic activity, an increase in vasomotor center activity and a release of neurohumoral factors. This review will summarize the basic science studies that have contributed to our understanding about mechanisms through which SCS produces beneficial effects when used in the treatment of vascular diseases. Furthermore, this review will particularly focus on the antidromic mechanisms of SCS-induced vasodilation in the lower limbs and feet.

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“…eripheral arterial disease (PAD) has been estimated to reduce quality of life in approximately 2 million symptomatic Americans, 1 and millions more Americans without claudication are likely to suffer PAD-associated impairment. 2 PAD is a strongly age-dependent condition that contributes significantly to morbidity and healthcare expenditures in the elderly: There are 413 000 discharges per year with chronic PAD, 88 000 hospitalizations involving lower-extremity arteriography, and 28 000 discharges citing embolectomy or thrombectomy of lower-limb arteries.…”

mentioning

confidence: 99%