Peripheral Arterial Disease

Golomb, Beatrice A.; Dang, Tram; Criqui, Michael H.

doi:10.1161/circulationaha.105.593442

Cited by 447 publications

(183 citation statements)

References 69 publications

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“…The effect of PAD on overall mortality has recently been summarized. 7 Our finding of lack of interaction of diabetes and CAD on mortality suggests that PAD overwhelms the independent effect of CAD on mortality in diabetic subjects. Although presence of diabetes is considered equivalent to presence of CAD by the National Cholesterol Education Program (NCEP) guidelines, 6 as shown in the East-West study, even in that study the mortality in subjects had both CAD and diabetes was 45% compared to 20% in diabetics without CAD.…”

Section: Discussionmentioning

confidence: 75%

“…To maximize dollar cost value, the priority target group should be the elderly, where the increase in DM prevalence is highest. Peripheral arterial disease prevalence is strongly age dependent 7 shows the prevalence of DM is also highest among the oldest cohort. The effect of PAD on overall mortality has recently been summarized.…”

Section: Discussionmentioning

confidence: 99%

“…6 Despite data suggesting that PAD may have an even stronger association with cardiac and cerebrovascular related mortality than prior history of myocardial infarct, subjects with PAD do not get the same proactive evaluation and treatment from physicians. 7 We report on the impact of DM on short-term and longterm mortality in a large cohort of patients discharged with a diagnosis of PAD from any VA medical center in the United States between the time period October 1990 through September 1997. The effect of the presence of coronary artery disease (CAD), with or without DM, on mortality in PAD patients was also investigated.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes and Peripheral Arterial Disease in Men: Trends in Prevalence, Mortality, and Effect of Concomitant Coronary Disease

Kamalesh

Shen

2009

Clinical Cardiology

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Background: Recent data on trends in diabetes mellitus (DM) prevalence and long-term effect on mortality in peripheral arterial disease (PAD) subjects is lacking. Methods: All subjects discharged from any VA medical center between October 1990 to September 1997 with an International Classification of Diseases (ICD)-9 code for PAD and DM in the discharge summary were retrospectively identified. Demographic data were extracted from the database. Mortality data were obtained from the Beneficiary Information and Resource Locator. Outcome measures were age specific DM prevalence over time, and short-term and long-term mortality. Results: Of 33, 629 patients with PAD, 9474 (29%) had DM. Diabetes mellitus subjects were less likely to be white and had more comorbidities. Mean length of hospital stay was greater for DM (22.3 d vs 18.7 days, P < 0.001). Mortality was higher for DM at 180 days (9.8% vs 8.4%, P < 0.001), 1 year (16.4% vs 13.7%, P < 0.001), and continues to increase at 8 years of follow-up. Logistic regression analysis showed no interaction between DM and coronary artery disease (CAD). Conclusions: Diabetes mellitus increases all-cause mortality in subjects with PAD starting at 6 months postdischarge and continues to be higher even at 8 years of follow-up. There was a lack of interaction of DM and CAD on mortality in this cohort of subjects with PAD.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diabetes and Peripheral Arterial Disease in Men: Trends in Prevalence, Mortality, and Effect of Concomitant Coronary Disease

Kamalesh

Shen

2009

Clinical Cardiology

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“…It is important to identify prognostically important CAD that may require revascularization prior to transplantation 37. Evidence of atherosclerotic vascular disease involving other vascular beds, particularly peripheral arterial disease, may help identify patients with advanced coronary atherosclerosis 38, 39, 40, 41. Since peripheral arterial disease is highly associated with CAD, it may be reasonable to pursue left heart catheterization in patients with peripheral arterial disease despite negative stress tests.…”

Section: Cad In Patients With Esrdmentioning

confidence: 99%

Diagnosis and Management of Cardiovascular Disease in Advanced and End‐Stage Renal Disease

Bhatti

Galougahi

Paz

et al. 2016

JAHA

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“…(7) Additionally, the extent of symptomatic PAD has a substantial influence on outcome: claudicants have a considerably better prognosis compared to patients with critical limb ischaemia. (8,9) The latter is a severe disease and the consequences can be direamputation, disability and death. (10)(11)(12) Repeated hospitalisations and interventions are causing a high economic burden.…”

Section: Introductionmentioning

confidence: 99%