Screening for novel antibacterial agents based on the activities of compounds on metabolism of Escherichia coli: A microcalorimetric study

A novel “target constituent knock-out” strategy coupled with TLC, UPLC–ELSD and microcalorimetry for preliminary screening of antibacterial constituents in Calculus bovis

“…In our previous study, we have found that artificial C. bovis had significant antibacterial activity on many microbes [11,12]. But, the corresponding antibacterial constituents of it, also the interactions of these antibacterial constituents and C. bovis were not definite.…”

“…But, almost all of these techniques still have some disadvantages [12,[25][26][27][28]. An alternative to these techniques that is universal, real-time, simple, non-invasive and non-destructive is IMC.…”

Antifungal evaluation of cholic acid and its derivatives on Candida albicans by microcalorimetry and chemometrics

“…In order to objectively evaluate the antifungal activities of the drugs, we tried to veritably depict the metabolic profile (shown in Fig. 2) including multiplying and non-multiplying metabolism of C. albicans by microcalorimetry based on the previous reports [14,31,32].…”

Fingerprint–efficacy study of artificial Calculus bovis in quality control of Chinese materia medica

“…In our previous study, we have found that artificial C. bovis and its components had significant antibacterial activities on multiple microbes (Kong et al, 2010c(Kong et al, , 2011. But, the corresponding antibacterial components representing the efficacy of artificial C. bovis have not been definite.…”