Screening for G6PD Deficiency in Blood Donor Population

Devi, Akoijam Mamata; Helen, Rose; Alwar, Vanamala; Chaithra, V.; Rameshkumar, Karuna

doi:10.1007/s12288-010-0039-x

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…The consequences of transfusing G6PD‐deficient RBCs are currently unknown, but a significantly lower 24‐h post‐transfusion recovery of stored RBCs from G6PD‐deficient donors when compared with normal RBCs was reported . Some cases of post‐transfusion haemolysis in recipients of G6PD‐deficient erythrocytes have been described , and the presence of G6PD deficiency in transfused RBCs has been observed and reported as causes of haemolysis after exchange transfusion in paediatric patients . Moreover, when donor blood is G6PD deficient, the efficacy of exchange transfusion for neonatal hyperbilirubinemia was significantly decreased as a consequence of a smaller drop in post‐exchange total serum bilirubin, causing an increase in duration of phototherapy and the need for repeat exchange transfusions .…”

Section: Discussionmentioning

confidence: 99%

“…The criteria for the selection of blood donors do not exclude the presence of this genetic disorder, and it was observed that specific donor RBC units are more likely to haemolyse during storage . Transfusion outcomes of RBC units from G6PD‐deficient donors have been recently discussed especially for high risk patients as premature infants and neonates, and patients with sickle cell disease (SCD) submitted to multiple transfusions . Moreover, checking for the presence of G6PD deficiency in blood donors or in RBC units was suggested in the regions with high frequency of G6PD deficiency .…”

Section: Introductionmentioning

confidence: 99%

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Glucose‐6‐phosphate dehydrogenase deficiency in Italian blood donors: prevalence and molecular defect characterization

et al. 2013

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In Italy, the presence of blood donors with G6PD deficiency is not a rare event and the class II severe variants are frequent. The identification of G6PD-deficient donors and the characterization of the molecular variants would prevent the use of G6PD-deficient RBC units when the haemolytic complications could be relevant especially for high risk patients as premature infants and neonates and patients with sickle cell disease submitted to multiple transfusions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Glucose‐6‐phosphate dehydrogenase deficiency in Italian blood donors: prevalence and molecular defect characterization

et al. 2013

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“…Because the prevalence of G6PD deficiency differs among populations, this also affects its prevalence among donors, depending on their racial/ethnic composition. For example, the reported frequency of G6PD deficiency among blood donors varies significantly: Nigeria (19·5%) , Canada (0·17%) , Brazil (3·2%) , Spain (0%) , Iran (16·3%) , India (0·8%) , Sardinia (6·6%) , Yemen (7·1%) , Saudi Arabia (10·7%) , Kuwait (6·5%) and the United States (0·3%) . Among G6PD‐deficient donors in Yemen and Kuwait, 97·2% and 80%, respectively, had Class II (<10% activity) variants with the majority being the Mediterranean variant .…”

Section: Transfusion Medicine and Cellular Therapymentioning

confidence: 99%

Glucose‐6‐phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks

et al. 2013

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The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce hemolysis in G6PD-deficient RBCs. Although it is not routine practice to screen healthy blood donors for G6PD deficiency, case reports identified transfusion of G6PD-deficient RBCs as causing hemolysis and other adverse events. In addition, some patient populations may be more at risk for complications associated with transfusions of G6PD-deficient RBCs because they receive RBCs from donors who are more likely to have G6PD deficiency. This review discusses G6PD deficiency, its importance in transfusion medicine, changes in the RBC antioxidant system (of which G6PD is essential) during refrigerated storage, and mechanisms of hemolysis. In addition, as yet unanswered questions that could be addressed by translational and clinical studies are identified and discussed.

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“…15 Shanthala et al found that there was no significant mean difference between the individuals with G6PD deficient and normal population, alike to the present study. 19 In deficient G6PD patients, the mean CD4 count (mean±SD) of patients was 299.5±53.6.…”

Section: Discussionmentioning

confidence: 96%

Prevalence of glucose-6-phosphate dehydrogenase deficiency in newly diagnosed HIV patients: a hospital-based cross-sectional study

Kamble

Sarkar

Ghosh

2022

Int J Community Med Public Health

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Background: The prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency is 8.5% in India. G6PD deficient individual have different outcomes with certain drugs and result in unexpected events that could be even fatal. HIV affected individuals with G6PD deficient have inherently worse outcomes when they start on those drugs that precipitate the condition. We aimed to study the level of G6PD and its deficiency status among the newly diagnosed HIV patients.Methods: A cross-sectional study among the newly diagnosed HIV patients was conducted at a tertiary hospital, Kolkata. All the eligible participants (n=100) were recruited consecutively after obtaining the consent. The details on socio-demography, clinical history and investigations were extracted from them. The data were analysed using the appropriate statistical methods.Results: Out of 100 newly HIV diagnosed participants, the prevalence of G6PD deficiency was 12% (95% CI: 5.6- 18.3%). Participants belonging to tribal population, with familial history of haemolytic disease, history of haemolysis, and increased LDH levels were significantly associated with the deficient G6PD levels among the study participants. Conclusions: The prevalence of G6PD deficiency was high among the newly diagnosed HIV study population. Tribal population and familial history of haemolytic disorders had high number of deficiency and need to be screened for better clinical care.

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Screening for G6PD Deficiency in Blood Donor Population

Cited by 7 publications

References 3 publications

Glucose‐6‐phosphate dehydrogenase deficiency in Italian blood donors: prevalence and molecular defect characterization

Glucose‐6‐phosphate dehydrogenase deficiency in Italian blood donors: prevalence and molecular defect characterization

Glucose‐6‐phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks

Prevalence of glucose-6-phosphate dehydrogenase deficiency in newly diagnosed HIV patients: a hospital-based cross-sectional study

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