Background: The prevalence of Glucose-6-phosphate dehydrogenase (G6PD) deficiency is 8.5% in India. G6PD deficient individual have different outcomes with certain drugs and result in unexpected events that could be even fatal. HIV affected individuals with G6PD deficient have inherently worse outcomes when they start on those drugs that precipitate the condition. We aimed to study the level of G6PD and its deficiency status among the newly diagnosed HIV patients.Methods: A cross-sectional study among the newly diagnosed HIV patients was conducted at a tertiary hospital, Kolkata. All the eligible participants (n=100) were recruited consecutively after obtaining the consent. The details on socio-demography, clinical history and investigations were extracted from them. The data were analysed using the appropriate statistical methods.Results: Out of 100 newly HIV diagnosed participants, the prevalence of G6PD deficiency was 12% (95% CI: 5.6- 18.3%). Participants belonging to tribal population, with familial history of haemolytic disease, history of haemolysis, and increased LDH levels were significantly associated with the deficient G6PD levels among the study participants. Conclusions: The prevalence of G6PD deficiency was high among the newly diagnosed HIV study population. Tribal population and familial history of haemolytic disorders had high number of deficiency and need to be screened for better clinical care.
Non alcoholic steatohepatitis (NASH) which lies in the spectrum of the broader entity Non alcoholic fatty liver disease (NAFLD ) is emerging as a common cause of chronic liver disease.All the patients with NASH have elevated liver enzymes (almost two to three times the normal upper limit) and all of them have sonological abnormality (hepatomegaly and /or fatty inltration). Aim of this study was to measure prevalence of Non Alcoholic Steatohepatitis (NASH) in patients of ischaemic heart disease and hypertension. So, study was conducted in General Medicine Dept until sample size of 75 was reached. All necessary laboratory investigations and clinical parameters were checked. Prevalence of NASH in total study population with history of IHD and or HYPERTENSION is 12%.Conclusion we can say that, prevalence of NON ALCOHOLIC STEATO HEPATITIS (NASH), in patients with ischaemic heart disease and hypertension is low, but there is strong association of metabolic syndrome, with patients having NASH.
Rheumatoid arthritis is chronic inammatory disease that affects the joints. This results in painful joints, swelling and stiffness in the joints. The present prospective comparative study aimed to compare the USG Doppler ndings with the inammatory marker levels in being a better predictor of joint erosions in rheumatoid arthritis. Total 50 patients coming rheumatology and medicine OPD were studied for inammatory markers and ultrasonography ndings. Radiological investigations such as High resolution USG power Doppler (4-12 MHz) and x-ray of the affected joints were carried out. Majority of participants (60%) belonged to 31-50 years of age group and female gender (86%). The change in inammatory markers were found to be poorly correlated to joint erosions, while that of USG erosions was found to be strongly positively correlated with the same. Multivariate regression analysis showed that in presence all others also only delta USG erosion signicantly impacts delta VDH, or the gold standard(X Ray) for evaluation joint erosion This strongly proves that USG erosion is a better predictor of joint erosions than the other independent variables(inammatory markers).
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