Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain

Tagarro, Alfredo; Epalza, Cristina; Santos, Mar; Sanz-Santaeufemia, Francisco José; Otheo, Enrique; Moraleda, Cinta; Calvo, Cristina

doi:10.1001/jamapediatrics.2020.1346

Cited by 432 publications

(526 citation statements)

References 7 publications

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“…It is likely that test sensitivity is lower in mild cases and in children, possibly because of a low viral load. Considering that PCR is positive in only 11.2% of children requiring hospital admission for suspected COVID-19,8 it is not surprising that only one in 19 tests in our series gave a positive result. Alternatively, the appearance of chilblains could have been a late event in the disease course, and PCR would have turned negative by the time it was tested.…”

mentioning

confidence: 59%

Chilblains in children in the setting of COVID‐19 pandemic

Andina

Noguera‐Morel

Bascuas-Arribas

et al. 2020

Pediatric Dermatology

186

328

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BackgroundDifferent skin manifestations of COVID‐19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID‐19 pandemic.Material and methodsA retrospective review of 22 children and adolescents with chilblain‐like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID‐19 in Madrid, Spain.ResultsAll patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D‐dimer results, but without systemic symptoms or other laboratory anomalies. SARS‐CoV‐2 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow‐up, all cases showed spontaneous marked improvement or complete healing.ConclusionAcute chilblains were observed during COVID‐19 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown.

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mentioning

confidence: 59%

Chilblains in children in the setting of COVID‐19 pandemic

Andina

Noguera‐Morel

Bascuas-Arribas

et al. 2020

Pediatric Dermatology

186

328

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“…(10,11) It is further reassuring that children appear to be at lower risk of COVID-19 morbidity and mortality than the adult population in general, although severe infection still can occur. (13,20) The CDC morbidity and mortality report notes that among the 149,082 reported U.S. cases of COVID-19 for which age is known, only 2572 (1.7%) occurred in In summary, based on available information to date, it is unclear whether there is a significantly increased risk of COVID-19 morbidity among asthmatic children. (8,9) It is also unknown whether asthma medications such as high-dose inhaled corticosteroids or asthma biological therapies pose a risk in managing COVID-19 infections.…”

Section: The Role Of Asthma In Covid-19 Morbidity and Mortalitymentioning

confidence: 99%

“…As a result, good asthma control is essential as a precautionary measure during this time. (8,9,13,20)…”

Section: The Role Of Asthma In Covid-19 Morbidity and Mortalitymentioning

confidence: 99%

Managing Asthma during Coronavirus Disease-2019: An Example for Other Chronic Conditions in Children and Adolescents

Abrams

Szefler

2020

The Journal of Pediatrics

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“…However, it is di cult to reliably estimate what the risk is of a severe clinical outcome for children with COVID-19 in these different reports due, as noted, to heterogeneous enrolment criteria and disease management. [6,7]. One recent report summarizes the clinical features of nine infants aged < 1 year with SARS-CoV-2 infection.…”

Section: Introductionmentioning

confidence: 99%

Health-Care Organization For The Management and Surveillance of SARS-CoV-2 Infection in Children During Pandemic in Italy

Nunziata

Bruzzese

Poeta

et al. 2020

Preprint

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Background: In comparison with adults, severe acute respiratory syndrome (SARS-CoV-2) infection in children has a milder course. The management of children with suspected or confirmed coronavirus disease (COVID-19) needs to be appropriately targeted. Methods: We designed a hub-and-spoke system involving a Hub Centre to provide relevant healthcare information, based on the use of telemedicine and stringent admission criteria. Result: Between March and April 2020, the Hub Centre managed a total of 119 children (62 males, 52%; median age, 5.5 years; interquartile range [IQR], 2; 10) with suspected or confirmed COVID-19. Of the 119 children, 90 were managed in cooperation with family paediatricians and 29 with hospital-based physicians. In total, 8 (6.7%) children were hospitalised, with a median length of hospital stay of 10 days (IQR, 8.5 days; range, 4–22 days). Conclusion: case-by-case management allows a global evaluation in which the clinical condition is one determinant in medical decision-making along with the use of isolation to prevent the spread of COVID-19 among family members and cohabitants, and biocontainment measures. Large centres could coordinate paediatric COVID-19 cases through telemedicine, taking advantage of the generally milder presentation in children but also considering their dependence on adults and risk of infection spreading.

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Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain

Cited by 432 publications

References 7 publications

Chilblains in children in the setting of COVID‐19 pandemic

Chilblains in children in the setting of COVID‐19 pandemic

Managing Asthma during Coronavirus Disease-2019: An Example for Other Chronic Conditions in Children and Adolescents

Health-Care Organization For The Management and Surveillance of SARS-CoV-2 Infection in Children During Pandemic in Italy

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