Screen printed potentiometric sensor for therapeutic monitoring of rocuronium at the point of care

A review on advances in the development of electrochemical sensors for the detection of anesthetic drugs

“…Recently, ROC has been extracted from human plasma and was measured using gas chromatography coupled with mass spectrometry, liquid chromatography coupled with fluorimetry detector, mass spectrometry, and hydrophilic interaction liquid chromatography. 67 All these methods are very sensitive; however, they are time consuming, use expensive bulky equipment, require skilled person, and are not suitable for point of care applications. To overcome these difficulties, electrochemical detection of ROC can be used.…”

“…Fahem et al introduced an electroanalytical method for therapeutic monitoring of ROC blood levels by using modified SPE in a simple way without extraction and complex sample preparation steps. 67 Here, a PVC based screen-printed electrode (SPE) was fabricated with calix 6 arene as an ionophore for enhancing the sensing capability of ROC and the sensor characteristics of the developed SPE were evaluated by detecting ROC in biological samples and in pharmaceutical formulations. The SPE can be used to detect ROC with a concentration range of 1 × 10 −2 to 1 × 10 −6 mol L −1 with a rapid response time of 8 s and with an LOD lower than ROC C max in human plasma.…”

“…Rocuronium bromide (ROC), a quaternary ammonium neuromuscular blocking agent, is commonly used by anesthesiologists during surgical procedures for paralyzing patients. 67 The response to the ROC will be different in different patients in addition to the difficulty in predicting the optimum dose and duration of action in patients. 68 However, it is necessary to measure the blood levels of ROC by using a reliable analytical tool.…”