Scratch resistance of plasticized hydroxypropyl methylcellulose (HPMC) films intended for tablet coatings

Hanhijärvi, Kalle; Majava, Terhi; Kassamakov, Ivan; Heinämäki, Jyrki; Aaltonen, Juha; Haapalainen, Jonne; Hæggström, Edward; Yliruusi, Jouko

doi:10.1016/j.ejpb.2009.09.006

Cited by 9 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The working principle and structure of SWLI is described elsewhere. For details see Kassamakov et al [25,26], Hanhijärvi et al [20], and Paaver et al [17]. In the present study, we obtained three-dimensional (3D) images featuring 29 nm × 29 nm active pixel size from a 55 × 40 μm 2 area.…”

Section: Methodsmentioning

confidence: 89%

“…Sandler et al and Genina et al used SWLI to image 3D printed multi-layered DDSs [18,19]. Hanhijärvi et al applied SWLI to investigate the film surface properties of hydroxypropyl methylcellulose (HPMC)-coated tablets [20], while O’Bryan et al used it to image 3D printed microgels intended for bioprinting applications [21]. Recently, Wickström et al applied SWLI to characterize the surface texture and surface roughness of antibiotic-loaded fiber-reinforced composite implants [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

et al. 2019

Self Cite

View full text Add to dashboard Cite

We investigated and monitored in situ the wetting and dissolution properties of polymeric nanofibers and determined the solid-state of a drug during dissolution. Piroxicam (PRX) was used as a low-dose and poorly-soluble model drug, and hydroxypropyl methylcellulose (HPMC) and polydextrose (PD) were used as carrier polymers for electrospinning (ES). The initial-stage dissolution of the nanofibers was monitored in situ with three-dimensional white light microscopic interferometry (SWLI) and high-resolution optical microscopy. The physical solid-state characterization of nanofibers was performed with Raman spectroscopy, X-ray powder diffraction (XRPD), and scanning electron microscopy (SEM). We showed that PRX recrystallizes in a microcrystalline form immediately after wetting of nanofibers, which could lead to enhanced dissolution of drug. Initiation of crystal formation was detected by SWLI, indicating: (1) that PRX was partially released from the nanofibers, and (2) that the solid-state form of PRX changed from amorphous to crystalline. The amount, shape, and size of the PRX crystals depended on the carrier polymer used in the nanofibers and dissolution media (pH). In conclusion, the present nanofibers loaded with PRX exhibit a quasi-dynamic dissolution via recrystallization. SWLI enables a rapid, non-contacting, and non-destructive method for in situ monitoring the early-stage dissolution of nanofibers and regional mapping of crystalline changes (re-crystallization) during wetting. Such analysis is crucial because the wetting and dissolution of nanofibers can greatly influence the performance of nanofibrous drug delivery systems in pharmaceutical and biomedical applications.

show abstract

Section: Methodsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…This potentially sterile technique requires no sample preparation. Using image stitching it allows, when necessary, high resolution also across a large surface (up to 200×)18 Moreover, it can determine surface roughness Sq (ISO 25178) for an embedded surface without direct tactile access. It can measure stacked layers that are static or moving19.…”

Section: Resultsmentioning

confidence: 99%

Rapid interferometric imaging of printed drug laden multilayer structures

Sandler

Kassamakov

Ehlers

et al. 2014

Sci Rep

Self Cite

View full text Add to dashboard Cite

The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.

show abstract

“…HPMC is used in the pharmaceutical industry as a film-coating agent, thickener, hydrophilic matrix material, tablet binder, and as an ASD carrier. In addition, it has bioadhesive properties and resists microbial attack …”

Section: Common Types Of Cellulose Ethers; Syntheses Properties and A...mentioning

confidence: 99%

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

Arca¹,

et al. 2018

View full text Add to dashboard Cite

Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure-property-function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.

show abstract

Scratch resistance of plasticized hydroxypropyl methylcellulose (HPMC) films intended for tablet coatings

Cited by 9 publications

References 24 publications

Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam

Rapid interferometric imaging of printed drug laden multilayer structures

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

Contact Info

Product

Resources

About