<scp>UCP</scp>1 in sebaceous glands corresponds with increased antioxidant potential and not brown adipose tissue function

Miller, Colette N.; Yu, Ping; Ambati, Suresh; McKinney, Elizabeth C.; Avra, Tucker; Baile, Clifton A.; Meagher, Richard B

doi:10.1111/exd.12991

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…The findings that UCP-1 protein present in other tissue besides BAT in the Sunda porcupine was correlated with the report of Mori et al [14] and Miller et al [12]. To date,…”

Section: Discussionsupporting

confidence: 89%

“…Mori et al [14] have found immunohistochemical localization of UCP1 in the granular layers of the epidermis, sweat glands, hair follicles, and sebaceous glands of various parts of the human body. Miller et al [12] also reported the distribution of UCP1 in sebaceous glands in the mouse tail. The distribution and intensity of the UCP-1 in the Sunda porcupine skin showed that specific regions contributed to the presence of the UCP-1.…”

Section: Discussionmentioning

confidence: 95%

“…The study conducted by Mori et al [14] found mRNA and protein of UCP-1 present in human skin, including sebaceous glands, sweat glands and the epidermal layer -they speculated that the UCP-1 protein was thought to play a role in the thermoregulation of human skin. In addition, Miller et al [12] found that UCP-1 was distributed in the sebaceous glands of mice and played a vital role in serving alternative antioxidants.…”

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confidence: 99%

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Localization of uncoupling protein 1 (UCP-1) in the sebaceous gland of the dorsal region in the Sunda porcupine (<i>Hystrix javanica</i>)

Prawira

Novelina

Farida

et al. 2020

The Journal of Veterinary Medical Science

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Uncoupling protein 1 (UCP-1) was believed to be an exclusive protein found in the brown adipose tissue of small rodents and humans; however, recent studies show that the expression of UCP-1 protein has been found in the sebaceous glands of the mouse tail and human skin. There are a few reports about the presence of UCP-1 in the sebaceous glands of other rodents, such as the Sunda porcupine (Hystrix javanica), a wild spiny rodent commonly found in Indonesia with a large sebaceous gland. The aim of this study was to identify the presence of UCP-1 in the sebaceous glands on the skin of the Sunda porcupine. The skin from three regions (thoracodorsal, lumbosacral and apex caudal) of eight adult Sunda porcupines was used to detect UCP-1-immunopositive cells through immunohistochemistry. All three regions were found immunopositive to anti-UCP-1 antibody in the sebaceous gland of quill and hair follicles, and the epidermal layer in quill and hair follicles with various intensities. The result of immunohistochemistry revealed that the thoracodorsal and apex caudal region was the most intense immunoreaction followed by the lumbosacral region. These findings proved that the presence of UCP-1 was also identified in the sebaceous glands of other rodent (Hystrix javanica) and regions of the body, which has not been reported previously.

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