<scp>TGF</scp>‐β1, Smad‐2/‐3, Smad‐1/‐5/‐8, and Smad‐4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study

Karathanasi, Vasiliki; Tosios, Konstantinos I.; Nikitakis, Nikolaos G.; Piperi, Evangelia; Koutlas, Ioannis G.; Trimis, George; Sklavounou, Alexandra

doi:10.1111/jop.12016

Cited by 32 publications

(32 citation statements)

References 78 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The transforming growth factor-β/SMAD signaling pathway is less activated in CCOT than in ameloblastoma, indicating CCOT may show less cellular proliferation and less advanced cellular differentiation than ameloblastoma 74. Furthermore, CCOTs express fewer matrix metalloproteases (MMPs), tissue inhibitors of metalloproteinases (TIMP), growth factors, epidermal growth factor receptor, and extracellular signal-regulated kinase than odontogenic keratocysts (keratocystic odontogenic tumors).…”

Section: Calcifying Cystic Odontogenic Tumormentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

View full text Add to dashboard Cite

Calcifying epithelial odontogenic tumors (CEOTs) and ghost cell odontogenic tumors (GCOTs) are characteristic odontogenic origin epithelial tumors which produce calcifying materials from transformed epithelial tumor cells. CEOT is a benign odontogenic tumor composed of polygonal epithelial tumor cells that show retrogressive calcific changes, amyloid-like deposition, and clear cytoplasm. Differentially, GCOTs are a group of transient tumors characterized by ghost cell presence, which comprise calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT), and ghost cell odontogenic carcinoma (GCOC), all derived from calcifying odontogenic cysts (COCs). There is considerable confusion about COCs and GCOTs terminology, but these lesions can be classified as COCs or GCOTs, based on their cystic or tumorous natures, respectively. GCOTs include ameloblastomatous tumors derived from dominant odontogenic cysts classified as CCOTs, ghost cell-rich tumors producing dentinoid materials as DGCTs, and the GCOT malignant counterpart, GCOCs. Many authors have reported CEOTs and GCOTs variably express keratins, β-catenin, BCL-2, BSP, RANKL, OPG, Notch1, Jagged1, TGF-β, SMADs, and other proteins. However, these heterogeneous lesions should be differentially diagnosed to allow for accurate tumor progression and prognosis prediction.

show abstract

Section: Calcifying Cystic Odontogenic Tumormentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Lee

Kim

2014

Korean J Pathol

View full text Add to dashboard Cite

show abstract

“…Enamel proteins including amelogenin, ameloblastin, and amelotin, as well as TGF-β/SMADs, are more intensely expressed in AOTs than in ameloblastomas. Therefore, AOTs exhibit less aggressive biological behavior and increased cytodifferentiation and apoptosis than ameloblastomas 16,30…”

Section: Adenomatoid Odontogenic Tumormentioning

confidence: 99%

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Lee

Kim

2013

Korean J Pathol

View full text Add to dashboard Cite

Ameloblastomas and adenomatoid odontogenic tumors (AOTs) are common epithelial tumors of odontogenic origin. Ameloblastomas are clinico-pathologically classified into solid/multicystic, unicystic, desmoplastic, and peripheral types, and also divided into follicular, plexiform, acanthomatous, granular types, etc., based on their histological features. Craniopharyngiomas, derived from the remnants of Rathke's pouch or a misplaced enamel organ, are also comparable to the odontogenic tumors. The malignant transformation of ameloblastomas results in the formation of ameloblastic carcinomas and malignant ameloblastomas depending on cytological dysplasia and metastasis, respectively. AOTs are classified into follicular, extrafollicular, and peripheral types. Ameloblastomas are common, have an aggressive behavior and recurrent course, and are rarely metastatic, while AOTs are hamartomatous benign lesions derived from the complex system of the dental lamina or its remnants. With advances in the elucidation of molecular signaling mechanisms in cells, the cytodifferentiation of epithelial tumor cells in ameloblastomas and AOTs can be identified using different biomarkers. Therefore, it is suggested that comprehensive pathological observation including molecular genetic information can provide a more reliable differential diagnosis for the propagation and prognosis of ameloblastomas and AOTs. This study aimed to review the current concepts of ameloblastomas and AOTs and to discuss their clinico-pathological features relevant to tumorigenesis and prognosis.

show abstract

“…Enamel proteins including amelogenin, ameloblastin, and amelotin, as well as TGF-β/SMADs, are more intensely expressed in AOTs than in ameloblastomas. Thus resulting in lesser aggressive biological behavior and increased cytodifferentiation and apoptosis in AOT than ameloblastomas [35,36] . Philipsen et al [4] in their study have suggested to continue reporting of unusual or rare histomorphological features, immunohistochemical findings and applications of molecular biological techniques for better understanding of this unusual odontogenic tumour [27] .…”

mentioning

confidence: 99%

Controversial Odontogenic Hamartomas- Review on Their Pathogenesis and Histopathology

Banerjee¹,

Tanu²,

Singroha³

et al. 2017

Journal of Tumor

View full text Add to dashboard Cite

metimes understated. There always lays a big controversy depicting an entity as hamartoma. Hamartomas are frequently encountered in major organs like liver, lung, pancreas etc. but the occurrence in oral cavity is rare. The lesions enlisted in this review may not be true hamartomas but depicts strong correlation to neoplasms. Understanding the hamartomatous nature of an odontogenic entity will help us understanding the outcome of the treatment and chances of fatality HAMARTOMASHamartomas, which are dysmorphic or morphologically altered proliferation of cells native to the organ in which they arise, gain a certain size before ceasing their proliferation. This type of biologic behavior may be expansile and is locally resorptive of bone but does not invade adjacent tissue. ODONTOGENIC GINGIVAL EPITHELIAL HAMARTOMA (OGEH)There are two important sources that are responsible for the development of the odontogenic group of lesions; cell rests of Serres (remnants of dental lamina) and cell rests of Malassez (remnants of Hertwig epithelial root sheath). These cell rests are found as clusters which upon getting stimulus give rise to pathological entities. The terminology OGEH was initially suggested by Baden et al [1,2] . This lesion has a rare occurrence, prevalent mostly in the middle age group (3 rd to 5 th decade) and most commonly seen in females (M: F-1: 7) [1,2,3] . The lesion present as a slowly growing, recurrent in occurrence in the soft tissues like gingiva and vestibule. ABSTRACTOdontogenic tumour represents as growth and swellings of variedorigin. The histopathological features of hamartomatous odontogenic entities are not very distinct from neoplasms, but they exhibit different biological behavior. The pathobiology of these lesions is so-

show abstract

TGF‐β1, Smad‐2/‐3, Smad‐1/‐5/‐8, and Smad‐4 signaling factors are expressed in ameloblastomas, adenomatoid odontogenic tumors, and calcifying cystic odontogenic tumors: an immunohistochemical study

Cited by 32 publications

References 78 publications

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst

Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Controversial Odontogenic Hamartomas- Review on Their Pathogenesis and Histopathology

Contact Info

Product

Resources

About