<scp>T2</scp> Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance

Papadaki, Efrosini; Mastorodemos, Vasileios; Panou, Τheodora; Pouli, Styliani; Spyridaki, Eirini; Kavroulakis, Eleftherios; Kalaitzakis, Georgios; Maris, Thomas G.; Simos, Panagiotis G.

doi:10.1002/jmri.27233

Magnetic Resonance Imaging

2021

DOI: 10.1002/jmri.27233

|View full text |Cite

T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance

Efrosini Papadaki¹,

Vasileios Mastorodemos²,

Τheodora Panou³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, T2 relaxation can detect tissue damage in the normal-appearing WM that is missed by conventional imaging (Neema et al, 2009). Furthermore, a nonplaque MRI abnormality that is present in at least 25% of MS patients is diffusely abnormal WM (Lipp et al, 2019), and T2 relaxation was capable of evidencing such microstructural changes in relapsing-remitting (RR) MS (Papadaki et al, 2021).…”

mentioning

confidence: 99%

Non‐lesional white matter in relapsing–remitting multiple sclerosis assessed by multicomponent T2 relaxation

Bontempi,

Rozzanigo,

Marangoni

et al. 2023

Brain and Behavior

View full text Add to dashboard Cite

IntroductionThe purpose of the study is to investigate, by T2 relaxation, non‐lesional white matter (WM) in relapsing–remitting (RR) multiple sclerosis (MS).MethodsTwenty stable RR MS patients underwent 1.5T Magnetic Resonance Imaging (MRI) with 3D Fluid‐Attenuated Inversion‐Recovery (FLAIR), 3D‐T1‐weighted, and T2‐relaxation multi‐echo sequences. The Lesion Segmentation Tool processed FLAIR images to identify focal lesions (FLs), whereas T1 images were segmented to identify WM and FL sub‐volumes with T1 hypo‐intensity. Non‐lesional WM was obtained as the segmented WM, excluding FL volumes. The multi‐echo sequence allowed decomposition into myelin water, intra‐extracellular water, and free water (Fw), which were evaluated on the segmented non‐lesional WM. Correlation analysis was performed between the non‐lesional WM relaxation parameters and Expanded Disability Status Scale (EDSS), disease duration, patient age, and T1 hypo‐intense FL volumes.ResultsThe T1 hypo‐intense FL volumes correlated with EDSS. On the non‐lesional WM, the median Fw correlated with EDSS, disease duration, age, and T1 hypo‐intense FL volumes. Bivariate EDSS correlation of FL volumes and WM T2‐relaxation parameters did not improve significance.ConclusionT2 relaxation allowed identifying subtle WM alterations, which significantly correlated with EDSS, disease duration, and age but do not seem to be EDSS‐predictors independent from FL sub‐volumes in stable RR patients. Particularly, the increase in the Fw component is suggestive of an uninvestigated prodromal phenomenon in brain degeneration.

show abstract

mentioning

confidence: 99%

Non‐lesional white matter in relapsing–remitting multiple sclerosis assessed by multicomponent T2 relaxation

Bontempi,

Rozzanigo,

Marangoni

et al. 2023

Brain and Behavior

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

T2 Relaxometry Evidence of Microstructural Changes in Diffusely Abnormal White Matter in Relapsing–Remitting Multiple Sclerosis and Clinically Isolated Syndrome: Impact on Visuomotor Performance

Cited by 1 publication

References 0 publications

Non‐lesional white matter in relapsing–remitting multiple sclerosis assessed by multicomponent T2 relaxation

Non‐lesional white matter in relapsing–remitting multiple sclerosis assessed by multicomponent T2 relaxation

Contact Info

Product

Resources

About