<scp>PRDM</scp>16 rs2651899 Variant Is a Risk Factor for <scp>C</scp>hinese Common Migraine Patients

An, Xingkai; Ma, Qin; Lin, Qing; Zhang, Xiaorong; Lu, Cong-Xia; Qu, Hongli

doi:10.1111/head.12212

Cited by 37 publications

(30 citation statements)

References 19 publications

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“…Previously, we examined the variations among PRDM16 , LRP1 and TRPM8 in a small sample of Chinese migraine patients and found that PRDM16 was associated with MO susceptibility . This result was different from Freilinger's report, which may have been due to our small‐scale sample .…”

contrasting

confidence: 72%

Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility

Fang

et al. 2017

Clinical Genetics

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Several genome-wide association studies (GWASs) in Caucasian populations have identified 12 loci that are significantly associated with migraine. More evidence suggests that serotonin receptors are also involved in migraine pathophysiology. In the present study, a case-control study was conducted in a cohort of 581 migraine cases and 533 ethnically matched controls among a Chinese population. Eighteen polymorphisms from serotonin receptors and GWASs were selected, and genotyping was performed using a Sequenom MALDI-TOF mass spectrometry iPLEX platform. The genotypic and allelic distributions of MEF2D rs2274316 and ASTN2 rs6478241 were significantly different between migraine patients and controls. Univariate and multivariate analysis revealed significant associations of polymorphisms in the MEF2D and ASTN2 genes with migraine susceptibility. MEF2D, PRDM16 and ASTN2 were also found to be associated with migraine without aura (MO) and migraine with family history. And, MEF2D and ASTN2 also served as genetic risk factors for the migraine without family history. The generalized multifactor dimensionality reduction analysis identified that MEF2D and HTR2E constituted the two-factor interaction model. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially MO, among Chinese patients. It appears that there is no association with serotonin receptor related genes.

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contrasting

confidence: 72%

Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility

Fang

et al. 2017

Clinical Genetics

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“…Rs2651899 has also been confirmed to be a risk factor for migraine in a meta-analysis including both clinical- and population-based cohorts [21] and in MO patients in a Chinese cohort [29]. The minor allele of this SNP was associated with an increased risk of migraine also in our Swedish cohort.…”

Section: Discussionsupporting

confidence: 67%

A replication study of GWAS findings in migraine identifies association in a Swedish case–control sample

et al. 2014

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BackgroundMigraine is a common neurovascular disorder with symptoms including headache of moderate to severe intensity and recurring attacks. There is no cure for migraine today and the pathology is poorly understood. Common forms of migraine have a complex genetic background and heritability has been estimated to be around 50%. Recent genome-wide association studies (GWAS) on European and American migraine cohorts have led to the identification of new genetic risk factors for migraine.MethodsWe performed an association study in a Swedish population based cohort, investigating the frequency of eight single nucleotide polymorphisms (SNPs) recently identified as genetic risk factors for migraine in three GWAS, using available array data (Illumina Omni Express chip). The eight SNPs were rs2651899, rs3790455, rs10166942, rs7640543, rs9349379, rs1835740, rs6478241 and rs11172113. Because information on rs3790455, rs10166942 and rs7640543 was not directly available, we selected SNPs in high Linkage Disequilibrium (LD) with these three SNPs, and replaced them with rs2274316, rs1003540 and rs4075749, respectively.ResultsWe were able to replicate the association with rs2651899 and found a trend for association with rs1835740 in our Swedish cohort.ConclusionsThis is the first reported genetic association study of a Swedish migraine case control material. We have thus replicated findings of susceptibility loci for migraine in an independent genetic material, thereby increasing knowledge about genetic risk factors for this common neurological disorder.

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“…Finally, Chasman et al described association between SNPs in the PRMD16 , TRPM8 , and LRP1 genes. Recent studies identified association between an SNP in the SLC39A12 gene and the risk for migraine or MWoA in different populations, but failed to find association with SNPs in the GALNT16 gene . In addition, interethnic variability in the associations exists, as LRP1 was found to be associated with the risk for migraine in Indians, but not in Chinese or Swedish individuals …”

Section: Clinical Epidemiological Biochemical Experimental and Phmentioning

confidence: 99%

Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine

et al. 2015

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PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients

Abstract: Our data suggested that rs2651899 variant in PRDM16 plays a potential role in Chinese MO migraine susceptibility, and gender may not play a role.

Cited by 37 publications

References 19 publications

Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility

Multilocus analysis reveals three candidate genes for Chinese migraine susceptibility

A replication study of GWAS findings in migraine identifies association in a Swedish case–control sample

Diamine Oxidase rs10156191 and rs2052129 Variants Are Associated With the Risk for Migraine

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