“…Among the potential upstream modulators of AMPAR movements at the synapse, mTORC1 has been proposed to play a pivotal role in memory processes ( Bekinschtein et al, 2007 ; Lopez et al, 2015 ; Pereyra et al, 2021 ). mTORC1 regulates local protein translation in dendrites ( Tang et al, 2002 ; Hay and Sonenberg, 2004 ; Hoeffer and Klann, 2010 ; Raab-Graham and Niere, 2017 ) and its blockade is associated with downregulation of GluA1 levels during memory retrieval in the PSD ( Lopez et al, 2015 ; Pereyra et al, 2021 ) ( Figure 1B ). In the hippocampus, but not in the amygdala, downregulation of GluA1 levels is also observed in the synaptic plasma membrane fraction in rapamycin (selective mTORC1 inhibitor)-treated animals ( Lopez et al, 2015 ; Pereyra et al, 2021 ).…”