<scp>l</scp>‐selectin gene polymorphisms in Graves' disease

Chen, Haoyan; Cui, Bin; Shu, Wang; Zhao, Zhihui; Sun, Hua; Zhao, Yong; Li, Xiaoying; Ning, Guang

doi:10.1111/j.1365-2265.2007.02852.x

Cited by 11 publications

(9 citation statements)

References 44 publications

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“…In the current study, the frequencies of the 213 S (725T) alleles among the healthy controls was 0.334, and this was similar to those frequencies observed in Wuhan and Shanghai of Chinese healthy Han race (0.307 and 0.370, respectively) [8,12], but the frequencies were higher than those of European populations (0.139 and 0.160, respectively) [13,14]. Suggesting that the distribution of L-selectin gene frequencies might vary among the different ethnic groups.…”

Section: Discussionsupporting

confidence: 88%

The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke

Wei

Yan

et al. 2011

J Thromb Thrombolysis

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L-selectin is a member of the selectin family of cell adhesion molecules which are important in the transient attachment of leukocytes to endothelial cells, which plays a role in inflammation processes and is one of the earliest events in the pathogenesis of atherosclerosis. No studies have examined the association of this polymorphism with ischemic stroke. Therefore, we investigated that L-selectin gene polymorphism and its soluble level are associated with ischemic stroke in Chinese population. We analyzed single nucleotide polymorphisms of L-selectin gene Pro213Ser (P213S) in 265 patients with ischemic stroke and 280 age and sex matched controls, using PCR-RFLP and DNA sequencing method, while soluble L-selectin levels were measured by ELISA. There were significant differences in the genotype and allele frequencies of L-selectin gene P213S polymorphism between the group of patients with ischemic stroke and the control group (P < 0.05). Soluble L-selectin levels were increased in patients with ischemic stroke compared with controls (P < 0.01). Moreover, The P213S polymorphism of L-selectin was significantly associated with sL-selectin levels, the serum levels of L-selectin PP genotype carriers was significantly higher than no carriers in patients with ischemic stroke (P < 0.05). The P213S polymorphism of L-selectin and its sL-selectin levels are associated with ischemic stroke in Chinese population. Our data suggests that L-selectin gene may play a role in the development of ischemic stroke.

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Section: Discussionsupporting

confidence: 88%

The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke

Wei

Yan

et al. 2011

J Thromb Thrombolysis

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“…Moreover, SELE and SELL within the selectin gene cluster seem to be prone to contribute susceptibility to a single autoimmune disease together, as shown in the findings in IgA nephropathy 25 and coeliac disease. 26 In the light of the evidence in the association of SELL with GD, 9 the association of SELE with GD could be a reasonable deduction.…”

Section: Resultsmentioning

confidence: 99%

“…23,24 Recently, we identified the association of GD and specific SNPs within SELL by means of a case-control study. 9 In addition, the common variants in selectin gene cluster on chromosome 1q24-25, including SELE and SELL, are in nearly complete linkage disequilibrium (data from www.hapmap.org). The two selectin genes might therefore contribute to the susceptibility to GD through either a mutual interaction or a common pathway, though we did not observe any direct evidence in this study.…”

Section: Resultsmentioning

confidence: 99%

The common variants of E-selectin gene in Graves’ disease

et al. 2007

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Adhesion molecules are involved in cell invasion in autoimmune thyroid disease. It was also reported that patients with untreated Graves' disease (GD) had high serum level of soluble form of E-selectin (sE-selectin), the concentration of which correlated with the activity of the disease. The aim of the present study was to elucidate whether the common variants in Eselectin gene (SELE) were associated with the development of GD. Six tagSNPs within SELE were studied in 297 patients with GD and 208 healthy subjects in Chinese population. Our data showed that common SELE variants were associated with GD (P ¼ 0.012-0.036). Haplotype analysis of the single nucleotide polymorphisms revealed an association of a haplotype ATAACC with GD (P ¼ 0.005). Furthermore, quantitative trait analysis showed a significant association of SELE haplotype with sEselectin levels (P ¼ 0.0438). This study therefore could provide us to a certain degree the insight that common SELE variants may be associated with susceptibility to GD in Chinese population, though the limitation of sample size and multiple test problems exists.

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“…[112, 113]. Chen H, et al [114, 115] reported common L-selectin or E-selectin variants may be associated with susceptibility to Graves’ disease in Chinese population. Cytokines, a large group of non-enzymatic proteins, participate in the induction and effector phases of all inflammatory and immune responses, and are therefore likely to play a critical role in the development of autoimmune diseases [116].…”

Section: Hyperthyroidismmentioning

confidence: 99%

The New Perspectives on Genetic Studies of Type 2 Diabetes and Thyroid Diseases

Bi²,

Cui³

et al. 2013

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Recently, genome-wide association studies (GWAS) have led to the discovery of hundreds of susceptibility loci that are associated with complex metabolic diseases, such as type 2 diabetes and hyperthyroidism. The majority of the susceptibility loci are common across different races or populations; while some of them show ethnicity-specific distribution. Though the abundant novel susceptibility loci identified by GWAS have provided insight into biology through the discovery of new genes or pathways that were previously not known, most of them are in introns and the associated variants cumulatively explain only a small fraction of total heritability. Here we reviewed the genetic studies on the metabolic disorders, mainly type 2 diabetes and hyperthyroidism, including candidate genes-based findings and more recently the GWAS discovery; we also included the clinical relevance of these novel loci and the gene-environmental interactions. Finally, we discussed the future direction about the genetic study on the exploring of the pathogenesis of the metabolic diseases.

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l‐selectin gene polymorphisms in Graves' disease

Abstract: L-selectin gene polymorphisms are associated with GD susceptibility in Chinese patients.

Cited by 11 publications

References 44 publications

The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke

The association of L-selectin polymorphisms with L-selectin serum levels and risk of ischemic stroke

The common variants of E-selectin gene in Graves’ disease

The New Perspectives on Genetic Studies of Type 2 Diabetes and Thyroid Diseases

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