<scp>l</scp>‐Arginine and melatonin interaction in rat intestinal ischemia–reperfusion

Arslan, Seyfullah Oktay; Gelir, Ethem; Sayan, Hale; Özaçmak, Veysel Haktan

doi:10.1111/j.1472-8206.2005.00365.x

Cited by 10 publications

(7 citation statements)

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“…The process of inflammation is actually a response to various stimuli against those who have given organism. Some of these stimuli are trauma, infection, ischemia/reperfusion and immunological reactions (21,22). Carrageenan-induced paw oedema is a well-established model for evaluating acute inflammation and anti-inflammatory effect of candidate drugs (9).…”

Section: Discussionmentioning

confidence: 99%

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

et al. 2018

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The present study aimed to investigate the role of cannabinoid 2 (CB2) receptors in a rat model of acute inflammation. Therefore, the potential of anti-inflammatory effects of CB2 receptor agonist (GW405833), CB2 receptor antagonist (AM630), and diclofenac, were investigated in carrageenan induced paw oedema in rats: as were assessed by measuring paw oedema; myeloperoxidase (MPO) activity in paw tissue; malondialdehyde (MDA) concentration; glutathione (GSH) level in paw tissue for oxidant/antioxidant balance; cytokine (interleukin-1β, IL-1β; tumour necrosis factor-α, TNF-α) levels in serum; histopathology of paw tissue for inflammatory cell accumulations. The results showed that GW405833 or diclofenac significantly reduced carrageenan-induced paw oedema. GW405833 also inhibited the increase of MPO activity, the recruitment of total leukocytes and neutrophils, and MDA concentration during carrageenan-induced acute inflammation, along with reversed nearly to the normal levels the increased of TNF-α, and IL-1β in serum. AM630 did not affect inflammation alone however clearly reversed the effects of agonist when co-administered. The mechanism of GW405833's suppression of inflammation is supported by these results, which are achieved by the inhibition of neutrophil migration, which regulates the reduction of oxidative stress, TNF-α and IL-1β levels. Finally, the activation of CB2 receptor, by selective agonist, has a major role in peripheral inflammation, and in the near future, targeting the peripheral cannabinoid system as a promising alternative to treat inflammation diseases may be considered a novel pharmacologic approach.

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Section: Discussionmentioning

confidence: 99%

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

et al. 2018

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“…The activation of inflammatory cells such as polymorphonuclear leukocytes leads to fast exagreation of the onset of inflammatory reaction. Previous studies have shown that in the pathologenesis of I/R, there is an increase in the amounts of reactive oxygen and nitrogen species, cytokines, endotoxins, and neutrophils (2)(3)(4). Several studies have also demonstrated that neutrophils, adhesive molecules and endothelial cells are responsible for serious and deleterious cellular inflammatory dysfunction caused by intestinal I/R injury (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that in the pathologenesis of I/R, there is an increase in the amounts of reactive oxygen and nitrogen species, cytokines, endotoxins, and neutrophils (2)(3)(4). Several studies have also demonstrated that neutrophils, adhesive molecules and endothelial cells are responsible for serious and deleterious cellular inflammatory dysfunction caused by intestinal I/R injury (3,4). It is well known that the produced reactive oxygen or nitrogen species and oxidative damage are the main responsibles of cell death and organ dysfunction in intestinal I/R (3,5).…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Parlar

Arslan

2020

Turk J Surg

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“…It is well known that oxygen reperfusion of tissue is to aggravate the injury of cells (24). On this account re-oxygenation should be by steps in mine workers.…”

Section: Discussionmentioning

confidence: 99%

Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel Bir Çalışma

Çam

Arslan

2019

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

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OBJECTIVE: Mine workers exposed to dusts or toxic gasses in occupational atmospheric conditions. Pneumoconiosis and other lung diseases are charecterized by the pathogenesis of coal dust-caused pulmonary toxicity associated with reactive oxygen species (ROS). MATERIALS AND METHODS:This study was conducted to investigate the respiration failures and fibrosis in rats after being exposed to coal dust and gases in mine atmosphere. Another aim was to study the therapeutic effect of erdosteine as antioxidant therapy. Rats were exposed to mine ambience for four week, and then they were breathed in the clean air for four week. The respiratory functions of rats were recorded once a week for eight week, as in vivo. The fibrosis of lung tissue levels, the oxidant/antioxidant status, and cytokines of inflammation in bronchoalveolar lavage fluids (BALFs) were evaluated, at the end of the processes. RESULTS: We observed to be the beginning of respiratory abnormalities in animals exposed to coal dust in second week. The end of fourth week, there were the increase of respiratory frequency and along with the decrease of respiratory depth. The respiratory failures were not improved in clean ambience, moreover apnea were appearance in the end of six week (the second week of clean air). Deaths were 28% in animals. Erdosteine administer to rats could not fully abolished to the pulmonary toxicity, however could able to hold to toxicity, and also there were not dies in rats administered to erdosteine. Coal dust exposure was resulted in fibrosis with higher hydroxyproline (HP) levels, cytokine inflammation with higher interleukin-6 (IL-6) and tumor necrosis factoralpha (TNF-α) levels, and lipid peroxidation with an increased malondialdehyde (MDA) levels, according to the healthy. A dramatically run out of endogen antidote sulfide pools (GSH), and an increased MPO activity were dedected in the mine dusts and gasses exposure group, according to the healthy animals. High biochemical index of toxicity were partly balanced by erdosteine. CONCLUSIONS: Our experimental findings support the hypothesis that ROS is induced coal workers' pneumoconiosis. Re-oxygenation cannot be getting it together to reverse the pulmonary toxicity. On the top of it, it can make its pathogenesis further exaggerating and even worse. On this account we heartily speculate that reoxygenation should be by steps in mine workers. In addition the antioxidant therapy may be partly a choice be able to tolerate the coal dust-induced lung toxicity of mine workers. Çam ve Arslan. AU Sağlık Bil. Derg. Sayfa 1501 Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel bir çalışma Amaç: Maden işçileri çalışma ortamı koşullarında tozlara veya zehirli gazlara maruz kalmaktadır. Pnömokonyoz ve diğer akciğer hastalıkları, kömür tozu kaynaklı pulmoner toksisitenin reaktif oksijen türleriyle (ROS) ilişkili patogenezi ile karakterizedir. Yöntem: Bu çalışma, maden atmosferinde kömür tozu ve gazlarına maruz kaldıktan sonra ...

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l‐Arginine and melatonin interaction in rat intestinal ischemia–reperfusion

Cited by 10 publications

References 5 publications

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress

Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Kömür madeni ortamında tutulan sıçanlarda akciğer toksisitesinin in vivo solunum kayıtları ile değerlendirilmesi: Deneysel Bir Çalışma

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