Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects

Abstract

Cite this article as: Parlar A, Arslan SO. Thymoquinone reduces ischemia and reperfusion-induced intestinal injury in rats, through anti-oxidative and anti-inflammatory effects.

Chronically administered Agave americana var. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats

“…Thymoquinone is another phytochemical compound that provides antidiabetic and neuroprotective effects by modulating inflammation and oxidative stress ( Abdelmeguid et al, 2010 , Farkhondeh et al, 2018 ). In a study by Parlar et al, thymoquinone has been reported to own antioxidant and anti-inflammatory properties as its pretreatment in rats resulted in reduced malondialdehyde levels and restoration of glutathione peroxidase at site of injury ( Parlar and Arslan, 2020 ). In another study, thymoquinone treatment resulted in reduced Inflammatory cells and pro-inflammatory and inflammatory mediators in rat model of allergic airway inflammation ( Parlar and Arsalan, 2019 ).…”

Antioxidant Actions of Thymoquinone, Silymarin, and Curcumin on Experimental Aortic Ischemia-Reperfusion Model in Wistar Albino Rats

“…Thymoquinone can also reduce the inflammatory activity that occurs with I-R. This demonstrates its efficacy by reducing inflammatory cytokines and reducing tumor necrosis factor-α [ 31 ] . This anti-inflammatory activity caused by thymoquinone causes a decrease in the amount of ROS formed.…”

Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways

“…The protective effect and therapeutic values of thymoquinone have been documented for various conditions such as asthma ( Ammar el et al, 2011 ; Kalemci et al, 2013 ; Keyhanmanesh et al, 2014 ), wound healing ( Selçuk et al, 2013 ; Siriwattanasatorn et al, 2020 ), liver damage ( Zeinvand-Lorestani et al, 2018 ; Atteya et al, 2019 ), diabetes ( El-Shemi et al, 2018 ; Rani et al, 2018 ), degenerative diseases ( Angeles et al, 2016 ; Ebrahimi et al, 2017 ; Elibol et al, 2020 ), and inflammation-related diseases ( Pop et al, 2020 ). Thymoquinone has been recognized to exert anti-inflammatory and antioxidant properties ( Parlar and Arslan, 2020 ; Savran et al, 2020 ). However, the main concern in using thymoquinone is its delivery system.…”

“…The increasing number of studies on thymoquinone’s effect on various conditions and diseases demonstrate the compound’s significance as a therapeutic target, which is primarily mediated through changes in signaling pathways related to ROS scavenging and antioxidant production in inflammatory and degenerative diseases ( Parlar and Arslan, 2020 ; Tabeshpour et al, 2020 ; Tian et al, 2020 ; TÜrkÖz et al, 2020 ). Recently, there has been a surge of interest in thymoquinone as a treatment for neurodegeneration in the brain, such as that seen in Alzheimer’s disease (AD) and Parkinson’s disease (PD) ( Ebrahimi et al, 2017 ; Elibol et al, 2020 ).…”

“…Thymoquinone is the main extract present in Nigella sativa , a traditional remedy widely used in Middle East countries. Recent growing evidence has shown antioxidant, anti-inflammatory, anti-bacterial, anti-fungal, and anti-neurodegenerative properties of thymoquinone in various models ( Sedaghat et al, 2014 ; Parlar and Arslan, 2020 ; Pop et al, 2020 ).…”