<scp>IL</scp>‐1α/β and <scp>IL</scp>‐18 profiles and their impact on claudin‐1, loricrin and filaggrin expression in patients with atopic dermatitis

Michaelidou, M; Redhu, Davender; Kumari, Vandana; Babina, Magda; Worm, Margitta

doi:10.1111/jdv.19153

Cited by 4 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2J), whereas IL6 also showed a tendency for a strong increase. IL-1β was shown to induce the expression of K6a (Komine et al, 2001), while additionally activating transcription factor NF-κB, which can cause the downregulation of filaggrin and loricrin expression (Michaelidou et al, 2023). Moreover, mRNA levels of Tslp , a master regulator of type II skin immunity (Hasegawa et al 2022), were also vastly elevated (Fig.…”

Section: To the Editormentioning

confidence: 99%

Novel, postnatal manifestation of an epidermal barrier defect in a mouse model of isolated sulfite oxidase deficiency

Johannes,

Rübsam,

Löhr

et al. 2024

Preprint

View full text Add to dashboard Cite

Sulfite oxidase deficiency is a rare inborn error in metabolism leading to early childhood death due to rapidly progressing neurodegeneration. A new mouse model of sulfite oxidase deficiency carrying a homozygous deletion in the Suox gene resembles the human pathology in terms of neonatal death and elevation of sulfite and thiosulfate in plasma and urine, respectively. Homozygous Suox-/- mice are initially born healthy, display growth retardation starting at postnatal day 4 and die in average at day 9.6. Here we report that Suox-/- mice develop dry and scaly skin early postnatally, showing that sulfite oxidase is essential to maintain a functional skin barrier after birth. At postnatal day 5 Suox-/- mice develop altered epidermal morphology and dysregulated early and late keratinocyte differentiation accompanied by increased stress response. We propose a sulfite-induced cleavage of disulfide bonds in key epidermal proteins essential for a functional barrier.

show abstract

Section: To the Editormentioning

confidence: 99%