Immunomodulatory and anti-angiogenesis effects of excavatolide B and its derivatives in alleviating atopic dermatitis

Toward the Briarane Core via 1,3-Dipolar Cycloaddition

“…Briarane-type diterpenoids are a unique class of secondary metabolites produced by marine soft corals . Over 700 family members have been characterized, many of which display intriguing biological properties, such as antiviral, cytotoxic, anti-inflammatory, and immunomodulatory activities . These highly oxygenated diterpenes share an unusual trans -fused 6/10-bicyclic skeleton (bicyclo[8.4.0]­tetradecane) (Figure ), while the C1 quaternary carbon center and C2/C14 oxygen functionalities constitute the conserved stereocenter array found in most congeners.…”