Ficus extract—A promising agent for antimammary tumorigenesis: A review on current status and future possibilities

Abstract

Pharmacological studies have shown that various species of Ficus have antiviral, antidiarrheal, antipyretic, hypolipidemic, antidiabetic, antioxidant, anticancer, antiparasitic, antiangiogenic, anti‐inflammatory, antibacterial, antiplatelet, reproductive, dermatological, immunological, endocrine, and hepato and nephron protective effects. But there is no sufficient research on biomolecules present in the leaf extract of Ficus religiosa and its mechanism of action. We have previously reported that bioavailable constituents of F. religiosa leaf extract exert photosensitizing and apoptosis‐inducing capability through the generation of intracellular reactive oxygen species on breast cancer cells. In this review, we have evaluated the expression of checkpoint proteins of G1/S and sub G0 phase with wet lab data and also have done a data mining of other research for other potential mechanistic action of the F. religiosa leaf extract.

Extract of Ficus septica modulates apoptosis and migration in human oral squamous cell carcinoma cells

“…For example, cisplatin mediates apoptosis by increasing ROS production in malignant human testicular germ cells 54 . Remadevi et al reported that Ficus extract induce apoptosis through the generation of intracellular ROS on breast cancer cells 38 . Our results demonstrated that the FSB increase ROS production in an dose‐dependent manner in SCC2095 cells.…”

Phytochemical Insights into Ficus sur Extracts and Their Biological Activity

“…Multiple studies describe the anticancer potential of Ficus spp, ex. Ficus carica [ 46 , 47 ], Ficus salicifolia [ 46 ], Ficus religiosa [ 48 ], Ficus beecheyana [ 49 ], Ficus pandurata H [ 50 ] and Ficus exasperata (Vahl) [ 51 ], against various cancer cell lines, however, to the best of our knowledge, this is the first report showing Ficus sur stem bark extracts as a possible source of antineoplastic molecules.…”

Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

“…Moreover, several studies report the ability of these plant extracts to inhibit the proliferation mainly of breast cancer cells, but also of hematological cancer [47,48]. 14, caffeic acid (15), trigonelline (16), formic acid (17). Spectra were measured in D2O-buffer (pH 6.0) using TMSP as standard, residual water signal has been removed.…”

“…Spectra were measured in D2O-buffer (pH 6.0) using TMSP as standard, residual water signal has been removed. (14), caffeic acid (15), trigonelline (16), formic acid (17). Spectra were measured in D 2 O-buffer (pH 6.0) using TMSP as standard, residual water signal has been removed.…”

“…As previously mentioned, in cancer treatment, the contribution of natural drugs has been both historically and currently remarkable [11,15]. Moreover, the preventive or antitumor activity of plant extracts was explored, attributing the result to the combined action of various phytochemicals rather than a single molecule [16,17]. Epidemiological studies also established associations between certain dietary patterns and reduced cancer risk [18,19], and significant results were obtained in vitro and in vivo on different food secondary metabolites such as carotenoids, phenolic, and organosulfur compounds [20,21].…”