Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

Cappadone, Concettina; Mandrone, Manuela; Chiocchio, Ilaria; Sanna, Cinzia; Malucelli, Emil; Bassi, Vincenza; Picone, Giovanna; Poli, Ferruccio

doi:10.3390/plants9010026

Cited by 20 publications

(21 citation statements)

References 51 publications

(83 reference statements)

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“…Moreover, in the study of Lockowandt et al [29] where the cytotoxic effects of C. cyanus were evaluated, the authors did not report any toxic effects. However, several pharmacological studies have suggested that the cytotoxic effects and the biological activities of various Centaurea species are associated with their content in sesquiterpene lactones and flavonoids [25,31,98,99], although the solvents used for the acquisition of extracts may affect the phytochemicals composition in the extracts and therefore their in vitro cytotoxicity [32,100]. Therefore, any cultivation practices and processing of samples that may regulate the phytochemicals content of plants could also affect the bioactive properties of the obtained extracts.…”

Section: Cytotoxic Effectsmentioning

confidence: 99%

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

et al. 2020

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The aim of this report was to study the effect of salinity (control: 2dS/m, S1: 4 dS/m and S2: 6 dS/m) and harvest time (first harvest on 9 May 2018 and second harvest on 19 April 2018) on the growth and the chemical composition of Centaurea raphanina subsp. mixta plants. The plants of the first harvest were used for the plant growth measurements (fresh weight and moisture content of leaves, rosette diameter, number and thickness of leaves), whereas those of the second harvest were not used for these measurements due to the flowering initiation, which made the leaves unmarketable due to their hard texture. The results of our study showed that C. raphanina subsp. mixta plants can be cultivated under mild salinity (S1 treatment) conditions without severe effects on plant growth and yield, since a more severe loss (27.5%) was observed for the S2 treatment. In addition, harvest time proved to be a cost-effective cultivation practice that allows to regulate the quality of the final product, either in edible form (first harvest) or for nutraceutical and pharmaceutical purposes as well as antimicrobial agents in food products. Therefore, the combination of these two agronomic factors showed interesting results in terms of the quality of the final product. In particular, high salinity (S2 treatment) improved the nutritional value by increasing the fat, proteins and carbohydrates contents in the first harvest, as well as the tocopherols and sugars contents (S1 and S2 treatments, respectively) in the second harvest. In addition, salinity and harvest time affected the oxalic acid content which was the lowest for the S2 treatment at the second harvest. Similarly, the richest fatty acid (α-linolenic acid) increased with increasing salinity at the first harvest. Salinity and harvest time also affected the antimicrobial properties, especially against Staphylococcus aureus, Bacillus cereus and Trichoderma viride, where the extracts from the S1 and S2 treatments showed high effectiveness. In contrast, the highest amounts of flavanones (pinocembrin derivatives) were detected in the control treatment (second harvest), which was also reflected to the highest antioxidant activity (TBARS) for the same treatment. In conclusion, C. raphanina subsp. mixta plants seem to be tolerant to medium salinity stress (S1 treatment) since plant growth was not severely impaired, while salinity and harvesting time affected the nutritional value (fat, proteins, and carbohydrates) and the chemical composition (tocopherols, sugars, oxalic acid, fatty acids), as well as the bioactive properties (cytotoxicity and antimicrobial properties) of the final product.

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Section: Cytotoxic Effectsmentioning

confidence: 99%

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

et al. 2020

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“…Moreover, T. audibertii caused a significant activation of effector caspases [119], suggesting apoptotic cell death [121]. A strong cytotoxicity, also on venous endothelial cells (HUVEC), was recently reported [119], highlighting a potential use in the prevention of angiogenesis, an attractive target for cancer chemotherapy [122].…”

Section: Anticancer Activitymentioning

confidence: 99%

Section: Anticancer Activitymentioning

confidence: 99%

“…The hydroalcoholic extract of T. audibertii exerted an interesting antitumor potential against human U2OS osteosarcoma cells [119], by blocking cell population in G2/M phase and affecting the tumor suppressor p53 levels, such as several anticancer agents [120]. Moreover, T. audibertii caused a significant activation of effector caspases [119], suggesting apoptotic cell death [121]. A strong cytotoxicity, also on venous endothelial cells (HUVEC), was recently reported [119], highlighting a potential use in the prevention of angiogenesis, an attractive target for cancer chemotherapy [122].…”

Section: Anticancer Activitymentioning

confidence: 99%

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So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

Sanna

Maxia

Fenu

et al. 2020

Plants

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The last decades have recorded an increase of plant-based drug discovery processes. Indeed, natural products possess a superior chemical diversity as compared to synthetic ones, leading to a renewal in searching for new therapeutic agents from the plant kingdom. In particular, since the structural variety of natural compounds reflects the biodiversity of their source organisms, regions of the world with high biodiversity and endemism deserve particular interest. In this context, Sardinia Island (Italy), with 290 endemic taxa (12% of the total flora), is expected to provide unique and structurally diverse phytochemicals for drug development. Several research groups built up a large program dedicated to the analysis of Sardinian endemic species, highlighting their peculiar features, both in respect of phytochemical and biological profiles. On this basis, the aim of this review is to provide an up-to-date and comprehensive overview on ethnobotanical uses, biological properties and phytoconstituents of Sardinian endemic plants in order to support their beneficial potential and to provide input for future investigations. We documented 152 articles published from 1965 to June 2020 in which a broad range of biological activities and the identification of previously undescribed compounds have been reported, supporting their great value as sources of therapeutic agents.

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“…C. calcitrapa may be used, in a similar way to make artisanal cheese, a traditional dairy product 7 . Its healing properties have been known since ancient times in the traditional medicine of different nations; antipyretic, digestive, for constipation and diarrhea 9 .…”

Section: Introductionmentioning

confidence: 99%

The In vivo and in vitro antioxidant and anti-hemolytic effect of Algerian Centaurea calcitrapa L. extracts

Trabsa

Baghiani

Boussoualim

et al. 2020

J. Drug Delivery Ther.

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In the present study, aerial part of Centaurea calcitrapa L. were extracted with solvent of varying polarity allowed their separation into three main subfractions, the analysis of methanol crud (CrE), chloroform (ChE) and ethyl acetate (EaE) extracts, showed that the EaE contains the highest amount of flavonoids (50,71 ± 0,65 mg Eq / Quercetin g dry extract and 31,96 ± 0,39 mg Eq Rutin / g dry extract). Using DPPH assay, the highest activity was observed with EaE (IC50 = 0,037 ± 0,0006 mg / ml). The β-carotene / linoleic acid bleaching assay revealed that the extracts have a very important antioxidant activity. The results showed that CrE has the highest antioxidant activity. The antioxidant activity of the CrE is confirmed by an in vivo assay in mice, using two doses: CrD1 (50 mg/kg/day) and CrD2 (100 mg/kg/day) during 21 days. Total antioxidant capacity of plasma and red blood cells was measured. The half-life (HT50), which corresponds to 50% of cell lysis was calculated, the results showed that both groups treated with plant extract had a protective effect against erythrocytes hemolysis (CrD2: HT50= 167,3 ± 3,72 min). The CrD2 group showed a strong scavenging activity using DPPH assay (51,64 ± 5,24 %), higher than that of Vit C group (38,92 ± 1,72 %). All results confirmed that the extracts have a dose dependent effect on the growth of overall antioxidant defenses. These results support the use of this plant against anti-inflammatory diseases in traditional medicine. Keywords: Centaurea calcitrapa L., in vivo-antioxidant activity, DPPH, hemolysis, flavonoids.

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Antitumor Potential and Phytochemical Profile of Plants from Sardinia (Italy), a Hotspot for Biodiversity in the Mediterranean Basin

Cited by 20 publications

References 51 publications

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

So Uncommon and so Singular, but Underexplored: An Updated Overview on Ethnobotanical Uses, Biological Properties and Phytoconstituents of Sardinian Endemic Plants

The In vivo and in vitro antioxidant and anti-hemolytic effect of Algerian Centaurea calcitrapa L. extracts

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