<scp>HSPA6</scp>, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer

Zhang, Lihua; Zhuo, Huiqin; Hong, Zhijun; Hou, Jingjing; Cheng, Jia; Cai, Jun

doi:10.1002/jcla.24763

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…HeatMap revealed that IL7R, LTB, HSPA6, TYROBP, and TRDV2 were enriched in the clusters. Numerous studies have confirmed that IL7R, [12][13][14] HSPA6, [15][16][17] and TYROBP 18,19 are closely associated with human cancers, which suggests that T cells possess a strong ability of EC.…”

Section: Identification Of T Cell Marker Genes Expression Profilesmentioning

confidence: 95%

scRNA‐seq determines the characteristics of T cell marker genes to predict the prognosis of esophageal cancer

Meng,

Hu,

Qiang

et al. 2024

Precision Medical Sciences

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Esophageal cancer (EC) mainly includes two histological subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma, which is of high morbidity and mortality. With the continuous development of medical technology, the treatment of EC has been greatly improved, but its prognosis is still unfavorable. Recent single‐cell RNA‐sequencing (scRNA‐seq) is expected to bring breakthroughs in the treatment of EC. First, we identified T cell marker genes and generated signature by analyzing scRNA‐seq data from Expression Omnibus (GEO) database and TCGA database. Then, an immune prognostic model was constructed using the least absolute shrinkage and selection operator. We found that the survival rate of ESCC varied significantly among the low‐ and high‐risk groups. Two genes from T cell signature, DCPS and CYB5R3, were expressed in ESCC cells. Collectively, our study proposed a novel prognostic signature for ESCC patients based on T cell marker genes.

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Section: Identification Of T Cell Marker Genes Expression Profilesmentioning

confidence: 95%

scRNA‐seq determines the characteristics of T cell marker genes to predict the prognosis of esophageal cancer

Meng,

Hu,

Qiang

et al. 2024

Precision Medical Sciences

View full text Add to dashboard Cite

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HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer

Zhang

Zhuo

Hong

et al. 2022

Clinical Laboratory Analysis

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Interferon signaling and ferroptosis in tumor immunology and therapy

Hu,

Zhao,

et al. 2024

npj Precis. Onc.

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This study sought to elucidate the mechanisms underlying the impact of the interferon signaling pathway on Ferroptosis in tumor cells and its correlation with CD8 + T cell exhaustion. Using mouse models and single-cell sequencing, the researchers studied the interaction between CD8 + T cells and the interferon signaling pathway. Differential gene analysis revealed key genes involved in CD8 + T cell exhaustion, and their downstream factors were explored using bioinformatics tools. The expression levels of interferon-related genes associated with Ferroptosis were analyzed using data from the TCGA database, and their relevance to tumor tissue Ferroptosis and patients’ prognosis was determined. In vitro experiments were conducted to measure the levels of IFN-γ, MDA, and LPO, as well as tumor cell viability and apoptosis. In vivo validation using a mouse tumor model confirmed the results obtained from the in vitro experiments, highlighting the potential of silencing HSPA6 or DNAJB1 in enhancing the efficacy of PD-1 therapy and inhibiting tumor growth and migration.

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HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 27 publications

scRNA‐seq determines the characteristics of T cell marker genes to predict the prognosis of esophageal cancer

scRNA‐seq determines the characteristics of T cell marker genes to predict the prognosis of esophageal cancer

HSPA6, a novel prognostic and therapeutic biomarker, associated with Ming classification in gastric cancer

Interferon signaling and ferroptosis in tumor immunology and therapy

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