2018
DOI: 10.1002/aps3.1143
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HPLCMS detection of pyrrolizidine alkaloids and their N‐oxides in herbarium specimens dating back to the 1850s

Abstract: Premise of the StudyUnderstanding the phylogenetic distribution of defensive plant secondary metabolites is essential to the macroevolutionary study of chemically mediated plant–animal interactions. The chemical ecology of pyrrolizidine alkaloids (PAs) has been extensively studied in a number of plant–herbivore systems, including Apocynaceae (the milkweed and dogbane family) and Danainae (the milkweed and clearwing butterflies). A systematic survey is necessary to establish a detailed understanding of their oc… Show more

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Cited by 18 publications
(14 citation statements)
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“…We report the largest survey to date of PA occurrence in Apocynaceae, leveraging the long-term stability of PAs in dried leaves (Tasca et al, 2018), the taxonomically diverse collection of leaf samples that one of us (T.L.) has assembled for phylogenetic analysis, and advances in PA identification using HPLC-MS/MS to overcome the barriers that had previously precluded systematic study of their occurrence.…”
Section: Scanning For Retronecine-type Pas Via Hplc-ms/msmentioning
confidence: 99%
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“…We report the largest survey to date of PA occurrence in Apocynaceae, leveraging the long-term stability of PAs in dried leaves (Tasca et al, 2018), the taxonomically diverse collection of leaf samples that one of us (T.L.) has assembled for phylogenetic analysis, and advances in PA identification using HPLC-MS/MS to overcome the barriers that had previously precluded systematic study of their occurrence.…”
Section: Scanning For Retronecine-type Pas Via Hplc-ms/msmentioning
confidence: 99%
“…has assembled for phylogenetic analysis, and advances in PA identification using HPLC-MS/MS to overcome the barriers that had previously precluded systematic study of their occurrence. We also follow up on preliminary evidence of infraspecific polymorphism of PA presence in Echites umbellatus (Tasca et al, 2018) Apocynum cannabinum L. was used as a negative control because it is a chemically well-studied species from which PAs have not been reported (Abe and Yamauchi, 1994), and because it has a homospermidine synthase pseudogene and hence should not be able to produce PAs (unpublished data). Subjecting the negative control leaf sample to the four PREC scans resulted in a TIC with a signal to noise ratio lower than three to one (<3:1 S/N).…”
Section: Scanning For Retronecine-type Pas Via Hplc-ms/msmentioning
confidence: 99%
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