<scp>Helicobacter pylori</scp> eradication does not cause reflux oesophagitis in functional dyspeptic patients: a randomized, investigator‐blinded, placebo‐controlled trial

Ott, Eduardo A.; Mazzoleni, Luiz Edmundo; Edelweiss, Maria Isabel Albano; Sander, Guilherme Becker; Wortmann, André Castagna; Theil, Alexandro L.; Somm, G; Cartell, André; Rivero, Luis Fernando; Uchôa, Diego de Mendonça; Francesconi, Carlos Fernando de Magalhães; Prolla, João Carlos

doi:10.1111/j.1365-2036.2005.02461.x

Cited by 22 publications

(23 citation statements)

References 65 publications

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“…H. pylori eradication does not cause refl ux esophagitis in Western patients with functional dyspepsia ( 41,42 ). In Japanese health examinees, however, development of refl ux esophagitis was more common in patients cured of H. pylori than in patients positive for H. pylori ( 43 ).…”

Section: Discussionmentioning

confidence: 97%

Effect of Helicobacter pylori Infection and Its Eradication on Reflux Esophagitis and Reflux Symptoms

Nam

Choi

Ryu

et al. 2010

American Journal of Gastroenterology

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Section: Discussionmentioning

confidence: 97%

Effect of Helicobacter pylori Infection and Its Eradication on Reflux Esophagitis and Reflux Symptoms

Nam

Choi

Ryu

et al. 2010

American Journal of Gastroenterology

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“…H. pylori eradication could therefore explain part of the increase in the prevalence of reflux esophagitis as hypochlorhydria subsides. Although it has been described that among patients without an H. pylori infection reflux esophagitis is more common [17], evidence is inconclusive and contradicting results have been reported on whether eradication itself could cause reflux esophagitis [13,14,15,16]. More studies are required to investigate the true association between infection with H. pylori and esophagitis.…”

Section: Discussionmentioning

confidence: 99%

Open-Access Upper Gastrointestinal Endoscopy a Decade after the Introduction of Proton Pump Inhibitors and Helicobacter pylori Eradication: A Shift in Endoscopic Findings

Kerkhoven

Rijswijck²,

Rossum³

et al. 2007

Digestion

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Background/Aim: Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most prominent: findings at open-access upper gastrointestinal endoscopy have not been evaluated properly ever since. This study aims to compare the current prevalence of upper gastrointestinal endoscopic findings to the prevalence 15 years ago. Methods: Data about endoscopic findings of consecutive patients for the first time referred for open-access upper gastrointestinal endoscopy between January 2002 and December 2004 was collected from medical files. The prevalence of each specific finding was compared with data described in three historical populations about 15 years ago. Results: The current and historical study population consisted of 1,286 and 3,062 subjects, respectively. The prevalence of peptic ulcer disease and duodenitis significantly decreased by 12.6% (95% CI: 14.5–10.7) and 2.9% (95% CI: 4.5–1.3), respectively. On the other hand, the prevalence of reflux esophagitis and Barrett’s esophagus both significantly increased by 6.9% (95% CI: 4.2–9.6) and 2.1% (95% CI: 0.8–4.4), respectively. Conclusions: Compared to 15 years ago, the prevalence of specific findings at open-access upper gastrointestinal endoscopy has changed considerably.

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“…Studies were carried out in different subgroups (DU, GERD, functional dyspepsia) of patients (11)(12)(13)(20)(21)(22)(23)(24), and results obtained were controversial. Labenz et al reported a signifi cant increase in the incidence of erosive esophagitis during three years in H. pylori-eradicated vs. noneradicated DU patients (7).…”

Section: Discussionmentioning

confidence: 99%

De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study

Jonaitis¹,

Kupčinskas²,

Kiudelis³

et al. 2010

Medicina

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It remains unclear whether the Helicobacter pylori eradication may cause or provoke gastroesophageal reflux disease. Therefore, we aimed to elucidate the role of H. pylori eradication and other factors in the development of erosive esophagitis in patients with duodenal ulcer. Materials and methods. We enrolled 183 H. pylori-positive duodenal ulcer patients without erosive esophagitis. Final endoscopy was performed 12 months later or in case if ulcer relapse was suspected. H. pylori was diagnosed by the urease test and histology if the results of at least one of the tests were positive. A total of 142 patients were assigned to the eradication treatment. The control group included 41 volunteers – 20-mg omeprazole b.i.d. for 4 weeks was administered. Results. A total of 150 patients completed the study. Of the 119 patients, 70 (58.8%) were cured from H. pylori, and in 49 (41.2%) of patients, treatment of H. pylori was unsuccessful. All 31 controls remained H. pylori-positive. At the final endoscopy, erosive esophagitis was found in 19 (12.7%) patients. Erosive esophagitis developed in 8 (11.4%) successfully eradicated patients, in 9 (18.4%) unsuccessfully treated patients, and in 2 (6.5%) controls (P>0.05 comparing the groups). Multivariate logistic regression analysis revealed 3 factors at baseline, which were significant (P<0.05) in predicting the occurrence of erosive esophagitis: age more than 43 years (OR, 4.96; 95% CI, 1.47–16.71), nonerosive gastroesophageal reflux disease (OR, 3.96; 95% CI, 1.34–11.68), and smoking (OR, 3.17; 95% CI, 1.01–9.17). Conclusions. H. pylori eradication did not influence the incidence of erosive esophagitis in patients with duodenal ulcer during a one-year follow-up period. Pre-existing nonerosive gastroesophageal reflux disease, smoking, and older age are important predictors of de novo development of erosive esophagitis.

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Helicobacter pylori eradication does not cause reflux oesophagitis in functional dyspeptic patients: a randomized, investigator‐blinded, placebo‐controlled trial

Cited by 22 publications

References 65 publications

Effect of Helicobacter pylori Infection and Its Eradication on Reflux Esophagitis and Reflux Symptoms

Effect of Helicobacter pylori Infection and Its Eradication on Reflux Esophagitis and Reflux Symptoms

Open-Access Upper Gastrointestinal Endoscopy a Decade after the Introduction of Proton Pump Inhibitors and Helicobacter pylori Eradication: A Shift in Endoscopic Findings

De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study

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