d‐Mannose: Properties, Production, and Applications: An Overview

Abstract

d-Mannose is a C-2 epimer of d-glucose, which is a natural monosaccharide. It can be obtained from both plants and microorganisms. Chemical synthesis and biotransformation of d-mannose from d-fructose or d-glucose by using d-mannose isomerases, d-lyxose isomerases, and cellobiose 2-epimerase were intensively studied. d-Mannose is an important component of polysaccharides and glycoproteins. It has been widely used in the food, pharmaceutical, and poultry industries, acting as the source of dietary supplements, starting material for the synthesis of drugs and blocking colonization in animal feeds. d-Mannose is a glyconutrient with high research value in basic science because of its structure and function. This article presents a review of current studies on sources, characteristics, production, and application of d-mannose.

Regulating Cofactor Balance In Vivo with a Synthetic Flavin Analogue

“…[13] As shown in the Scheme 1, SBFAwere efficient for aerobic NAD + regeneration in vitro, and the order of catalytic activity of these SBFAappeared to be F1 > F2 > F4 > F3,w hich agrees well with our previous reports. Recently,sugars like d-mannose have been getting increasing attention for health care and pharmaceutical interests due to its potential biological activities.…”

Character and laxative activity of polysaccharides isolated from Dendrobium officinale

“…As an essential glyconutrient for human health, mannose is a popular nutritional and health-beneficial food supplement (Hu et al, 2016). It has been reported that mannose can act as a prebiotic, with beneficial effects on bowel functions and dysbiosis of the microecology in the human body (Umemura, Asano, Hoshino, & Iino, 2004).…”

Production of d‐mannose from d‐glucose by co‐expression of d‐glucose isomerase and d‐lyxose isomerase in Escherichia coli

“…In addition, it is an important glyconutrient for human health, and is recommended as a dietary supplement for infants and children. 6 In addition, it is also a key ingredient or intermediate for the synthesis of antitumor agents, 7 immunostimulatory agents, 8 auxiliary moisturizing agents, 9 D-mannitol, 10 and vitamins. 11 Furthermore, D-mannose is an effective additive in animal feeds, which can inhibit the growth of intestinal pathogens.…”

“…Although several chemical synthesis processes of D-mannose from D-glucose have been reported, the reaction temperature and acid concentration are under strict control. 6 In addition, all the drawbacks of the chemical methods, including the sophisticated purification processes, application safety, and the chemical waste and by-product, make it become less desirable. 13 As a result, the enzymatic approaches to D-mannose production have recently gained researchers' attention.…”