CD33⁺/HLA‐DR^neg and CD33⁺/HLA‐DR^+/− Cells: Rare Populations in the Human Decidua with Characteristics of MDSC

Abstract

We characterized a new population of CD33(+) /HLA-DR(neg) and CD33(+) /HLA-DR(+/-) cells in human early pregnancy decidua with properties of classical MDSC and thus potentially being an important player in immune tolerance in pregnancy.

Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer

“…Unlike murine MDSCs, the human MDSCs are ambiguously defined owing to the lack of specific markers. The human MDSCs are commonly defined as CD11b + CD33 + HLA-DR low/- cells [ 19 ]. Some investigators affirmed that human MDSCs could also be subdivided into two main subsets: CD15 + CD14 - CD11b + CD33 + HLA-DR low/- G-MDSCs and CD15 - CD14 + CD11b + CD33 + HLA-DR low/- M-MDSCs, but with no agreement to date [ 20 ].…”

Myeloid-Derived Suppressor Cells in Pregnancy and the Neonatal Period

“…Levels of GR-MDSC were highest during early gestation ( 15 , 16 ) and dropped within a few days postpartum to levels of non-pregnant women ( 15 ). In human placenta GR-MDSC were shown to be enriched in comparison to maternal and fetal blood ( 17 ) and mainly located in decidua and intervillous space ( 17 , 18 ). Genetic analyses revealed that they descend from maternal origin ( 17 ).…”

“…Changes in T-cell function are one of the best examined mechanisms mediating maternal-fetal tolerance ( 33 ). In humans, it could have been shown that GR-MDSC during pregnancy inhibit T-cell proliferation ( 15 , 17 , 18 ), express ArgI, iNOS and IDO and produce ROS ( 15 , 18 , 30 ). ArgI expression led to downregulation of CD3ζ chain on T cells and to decreased T-cell proliferation ( 31 ), while inhibition of ArgI restored T-cell proliferation in-vitro ( 17 ).…”

The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

“…However, human MDSCs cannot be uniformly identified by specific markers so far. Some investigators defined human MDSCs as CD11b+CD33+HLA-DRlow/− cells [4], but without consensus in academics. Bartmann et al affirmed in their study that human MDSCs could also be subdivided into two main subsets: CD15+CD14−CD11b+CD33+HLA-DRlow/− G-MDSCs and CD15−CD14+CD11b+CD33+HLA-DRlow/− M-MDSCs [4].…”

“…Some investigators defined human MDSCs as CD11b+CD33+HLA-DRlow/− cells [4], but without consensus in academics. Bartmann et al affirmed in their study that human MDSCs could also be subdivided into two main subsets: CD15+CD14−CD11b+CD33+HLA-DRlow/− G-MDSCs and CD15−CD14+CD11b+CD33+HLA-DRlow/− M-MDSCs [4]. The reason why these cells with different origins can be summarized as one group is that they share two common characteristics: one is that they are all staying in an immature state; the other is that they are able to exert strong suppressive activity on T cell proliferation and activation.…”