<scp>CD</scp>24 and <scp>CD</scp>44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators?

Ianez, Renata Carolina Fraga; Coutinho‐Camillo, Cláudia Malheiros; Buim, Marcilei Eliza Cavicchioli; Pinto, Clóvis Antônio Lopes; Soares, Fernando Augusto; Lourenço, Sílvia Vanessa

doi:10.1111/his.12109

Cited by 10 publications

(7 citation statements)

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“…Wein et al reported expression of HA and its associated receptors CD44 and HARE in mucoepidermoid carcinoma [ 19 ]. Other studies using qPCR support these findings; CD44 was overexpressed in the tumors from salivary glands compared with normal salivary glands [ 20 ]. CD44v3 and v6 variants are widely expressed by the myoepithelial cells of salivary gland tumors and are correlated with the ability to self-renew [ 21 ].…”

Section: Discussionmentioning

confidence: 56%

Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior

2016

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BackgroundThe most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the most common site in which this tumor arises. CD44, a trans-membrane glycoprotein, is an adhesion molecule of cell surface that play a role in the connections between cell-cell and cell-matrix. Many malignant tumors express high levels of CD44, thus, CD44 may be used as an indicator of aggressive behavior of some human malignancy. We evaluate CD44 expression in different grades of mucoepidermoid carcinoma and determine whether expression of CD44 can be used to predict tumor aggressiveness.MethodsFifteen cases of mucoepidermoid carcinoma were retrieved from the oral pathology archives and grouped according to the histological grade as well as the clinical behavior regarding metastases and/or recurrence. Tissue sections were immunohistochemically stained for CD44. CD44 staining was scored for intensity and proportion of cells stained.ResultsA higher proportion of high-grade tumor tissues showed moderate or strong CD44 staining compared to low-grade tumors. Additionally, CD44 expression was stronger in tumors from patients with recurrences or metastases, but theses differences were not statistically significant.ConclusionOur result showed that mucoepidermoid carcinomas are immunohistochemistry positive to CD44 compare to normal. A trend of CD44 expression associated with different histological grading and aggressive behavior of this tumor.

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Section: Discussionmentioning

confidence: 56%

Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior

2016

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“…Galectin-3 þve 26 CK14 and p63 þve 5 DOG1 staining is þve 5 Strong expression of PCNA, p53, and EGFR weak expression of c-erbB2 25 Carbonic anhydrase VI, and salivary proline-rich proteins 12 Strongly positive for TNFa 25 Keratin, alpha-1-antichymotrypsin, alpha amylase, vasoactive intestinal polypeptide, and myoepithelial markers 27 Proteins of the STAT3/PIM1/BCL-2 pathway 25 Positive for pAKT 25 j o u r n a l o f o r a l b i o l o g y a n d c r a n i o f a c i a l r e s e a r c h 4 ( 2 0 1 4 ) 1 2 7 e1 3 4…”

Section: Mec Acinic Cell Carcinomamentioning

confidence: 99%

“…In salivary gland neoplasms, only a few reports have shown alterations in KIT and that too in the ACC. 27 It is believed that the elevated expression of HIF-2a, TWIST2 and SIP1 can contribute to invasion and metastasis of ACC. 28 Hepatocyte growth factor (HGF), a protein that causes morphogenesis and dispersion of epithelial cells, has been found to increase ACC scattering and perhaps invasiveness.…”

Section: Random Tumor Markers In Sgtsmentioning

confidence: 99%

A review: Immunological markers for malignant salivary gland tumors

Namboodiripad¹

2014

Journal of Oral Biology and Craniofacial Research

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Salivary gland cancers are rare. Around 8 out of 10 salivary gland tumors (80%) are in the parotid. Just fewer than 2 out of 10 salivary gland cancers develop in the other two salivary glands - the submandibular or sublingual glands. Fewer than 1 in 10 cancers start in the minor salivary glands. There are many different types of salivary gland cancers. The most common is mucoepidermoid carcinoma (MEC). Just over 3 out of 10 (25-35%) salivary gland cancers (SGT, SGC) are of this type. The others include adenoid cystic carcinoma (ACC), acinic cell carcinoma, carcinoma ex-pleomorphic adenoma (Ca-PA), polymorphous low grade adenocarcinoma (PLGA) and some newly discovered salivary gland tumors. Because of the infrequency of salivary gland tumors and their complex histopathological diagnosis, it is difficult to exactly predict their clinical course by means of its recurrence, malignant progression or metastasis. Salivary gland tumors always pose problems in diagnosis. This review provides an insight into the recent concepts and immunohistochemical markers to diagnose the malignant salivary gland tumors (SGT), thus guiding the Ear, Nose and Throat specialists, Oral and Maxillofacial Surgeons, General Pathologists and other medical and dental specialists thereby enabling them to make correct diagnosis and provide the appropriate treatment.

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“…13,17,27,28 However, research on the participation of these cells in benign and malignant salivary gland tumors is still in an early stage and studies investigating the expression of OCT4 and CD44 in these tumors are scares. 5,29,30 In this study, evaluation of the immunohistochemical expression of OCT4 revealed immunostaining in all cases, with most PAs, MECs, and CACs exhibiting strong predominantly nuclear expression in cells of the tumor parenchyma. These data agree with the findings of Habu et al 27 and Qiao et al 31 who demonstrated predominantly nuclear expression of OCT4 in squamous cell carcinomas of the head and neck.…”

Section: Discussionmentioning

confidence: 54%

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

et al. 2021

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The aim of this study was to identify tumor parenchyma cells exhibiting immunohistochemical profile of stem cells by evaluating the immunoreactivity of OCT4 and CD44 in a number of cases of salivary gland neoplasms. The sample consisted of 20 pleomorphic adenomas, 20 mucoepidermoid carcinomas, and 20 adenoid cystic carcinomas located in major and minor salivary glands. The expression of OCT4 and CD44 was evaluated by the percentage of positive cells and the intensity of expression. All studied cases showed positive expression of OCT4 and CD44 and higher values than the control groups. For OCT4, luminal and non-luminal cells were immunostained in the case of pleomorphic adenomas and adenoid cystic carcinomas. Moreover, the immunoreactivity of CD44 was particularly evident in the nonluminal cells of these lesions. In mucoepidermoid carcinomas, there was immunoreactivity for both markers in squamous and intermediate cells and absence of staining in mucous cells. For both markers, a significantly higher immunostaining was verified in neoplasms located in the major salivary glands compared with lesions in minor salivary glands (p<0.001). In the total sample and in minor salivary glands, malignant neoplasms exhibited higher immunoreactivity for OCT4 than pleomorphic adenoma. A significant moderate positive correlation (r = 0.444 and p ≤ 0.001) was found between OCT4 and CD44 immunoexpression in the total sample. The high expression of OCT4 and CD44 may indicate that these proteins play an important role in identifying tumor stem cells.

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CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators?

Abstract: PA and stem cells share the expression of CD24 and CD44; their value as markers of neoplastic cell multipotency and the implications of their expression for tumour behaviour are yet to be determined.

Cited by 10 publications

References 29 publications

Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior

Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior

A review: Immunological markers for malignant salivary gland tumors

Immunohistochemical expression of OCT4 and CD44 in major and minor salivary gland neoplasms

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