<scp>CASC</scp>2: An emerging tumour‐suppressing long noncoding <scp>RNA</scp> in human cancers and melanoma

Yu, Xuezhong; Zheng, Heyi; Tse, Gary; Zhang, Lin; Wu, William Ka Kei

doi:10.1111/cpr.12506

Cited by 40 publications

(29 citation statements)

References 38 publications

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“…Of greater importance considering the present study, lncRNAs have been also identified as crucial regulators in the carcinogenesis and progression of multiple types of cancer, where they function as oncogenes or tumor suppressors, depending on the cancer type and the prevailing circumstances (8-10). In the case of SM, an increasing body of evidence has indicated that lncRNAs are also involved in the regulation of the expression and function of established oncogenes or tumor suppressors, either post-transcriptionally or via chromatin regulation (11-13). Nevertheless, only a small number of lncRNAs have been functionally characterized at present, and the mechanisms underlying their biological functions are yet to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR‑367/PTEN axis

Mou

et al. 2019

Int J Oncol

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Long intergenic noncoding RNA 00961 (Linc00961) has been identified as a tumor suppressor in various types of cancer. However, the critical roles of Linc00961 in the carcinogenesis and progression of skin melanoma (SM) are yet to be fully elucidated. The present study revealed via reverse transcription-quantitative PCR analysis that Linc00961 was downregulated in the tissues of patients with SM compared with benign nevi, and in A375, A2058 and SK-MEL-28 cell lines compared with human melanocytes. Furthermore, overexpression of Linc00961 inhibited cell proliferation, and promoted the apoptosis of A375 and SK-MEL-28 cells in vitro and in vivo , as determined by Cell Counting Kit-8 and flow cytometry assays, and tumor xenograft studies, respectively. Overexpression of Linc00961 also led to an attenuation of the migration and invasive capabilities of A375 and SK-MEL-28 cells, measured using Transwell assays. Functionally, it was demonstrated that Linc00961 acted as a competing endogenous RNA (ceRNA) by competitively sponging microRNA-367 (miR-367) in A375 and SK-MEL-28 cells; restoration of miR-367 rescued the inhibitory effects of Linc00961 on A375 and SK-MEL-28 cells. Finally, it was observed that phosphate and tension homology deleted on chromosome 10 (PTEN), an established target of miR-367 in A375 and SK-MEL-28 cells, was positively regulated by Linc00961, and its inhibition reversed the inhibitory effects of Linc00961 on the proliferation and invasion of A375 and SK-MEL-28 cells. Collectively, the present study revealed that Linc00961 was downregulated inSM, and furthermore, Linc00961 was identified as a ceRNA that inhibits the proliferation and invasion of A375 and SK-MEL-28 cells by modulating the miR-367/PTEN axis.

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Section: Introductionmentioning

confidence: 99%

Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR‑367/PTEN axis

Mou

et al. 2019

Int J Oncol

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“…The lncRNA CASC2 is a tumor suppressor gene, located on human chromosome 10( 67 ). CASC2 is closely associated with PH.…”

Section: Lncrnas and Phmentioning

confidence: 99%

Emerging role of long non‑coding RNAs in pulmonary hypertension and their molecular mechanisms (Review)

Qin

Yan

et al. 2020

Exp Ther Med

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Pulmonary hypertension (PH) is a life-threatening cardiopulmonary condition caused by several pathogenic factors. All types of PH are characterized by the excessive proliferation of pulmonary artery endothelial cells and pulmonary artery smooth muscle cells, apoptosis resistance, pulmonary vascular remodeling, sustained elevated pulmonary arterial pressure, right heart failure and even death. Over the past decade, next generation sequencing, particularly RNA-sequencing, has identified some long non-coding RNAs (lncRNAs) that may act as regulators of cell differentiation, proliferation and apoptosis. Studies have shown that lncRNAs are closely associated with the development of several diseases, including cardiovascular diseases. In addition, a number of studies have reported that lncRNAs, including maternally expressed gene 3, metastasis-associated lung adenocarcinoma transcript 1, taurine upregulated 1 and cancer susceptibility candidate 2, serve important roles in the pathogenesis of PH. Despite the development of novel drug treatments, the mortality rate of PH remains high with no evident downward trend. Therefore, certain lncRNAs may be considered as therapeutic targets for the treatment of incurable PH. The present review summarizes the latest research on lncRNAs and PH, aiming to briefly describe PH-associated lncRNAs and their mechanisms of action.

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“…For the 5 identified lncRNA markers, CASC2 has been reported to be associated with colorectal cancer [33][34][35]. Studies have revealed that the deregulation of CASC2 by miRNA hsa-mir-21 and hsa-mir-18a increases the proliferation and migration of cancer cells in colorectal cancer [33][34][35].…”

Section: General Commentsmentioning

confidence: 99%

Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma

Chen

Deng

et al. 2019

J Transl Med

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Background Numerous evidence has suggested that long non-coding RNA (lncRNA) acts an important role in tumor biology. This study focuses on the identification of novel prognostic lncRNA biomarkers predicting tumor recurrence in human colon adenocarcinoma. Methods We obtained the research data from The Cancer Genome Atlas (TCGA) database. The interaction among different expressed lncRNA, miRNA and mRNA markers between colon adenocarcinoma patients with and without tumor recurrence were verified with miRcode, starBase and miRTarBase databases. We established the lncRNA–miRNA–mRNA competing endogenous RNA (ceRNA) network based on the verified association between the selected markers. We performed the functional enrichment analysis to obtain better understanding of the selected lncRNAs. Then we use multivariate logistic regression to identify the prognostic lncRNA markers with covariates. We also generated a nomogram predicting tumor recurrence risk based on the identified lncRNA biomarkers and clinical covariates. Results We included 12,727 lncRNA, 1881 miRNA and 47,761 mRNA profiling and clinical features for 113 colon adenocarcinoma patients obtained from the TCGA database. After filtration, we used 37 specific lncRNAs, 60 miRNAs and 148 mRNAs in the ceRNA network analysis. We identified five lncRNAs as prognostic lncRNA markers predicting tumor recurrence in colon adenocarcinoma, in which four of them were identified for the first time. Finally, we generated a nomogram illustrating the association between the identified lncRNAs and the tumor recurrence risk in colon adenocarcinoma. Conclusions The four newly identified lncRNA biomarkers might be potential prognostic biomarkers predicting tumor recurrence in colon adenocarcinoma. We recommend that further clinical and fundamental researches be conducted on the identified lncRNA markers.

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CASC2: An emerging tumour‐suppressing long noncoding RNA in human cancers and melanoma

Cited by 40 publications

References 38 publications

Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR‑367/PTEN axis

Linc00961 inhibits the proliferation and invasion of skin melanoma by targeting the miR‑367/PTEN axis

Emerging role of long non‑coding RNAs in pulmonary hypertension and their molecular mechanisms (Review)

Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma

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