2013
DOI: 10.1016/j.toxicon.2013.06.023
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Scorpion venoms, kidney and potassium

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Cited by 20 publications
(22 citation statements)
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“…Of particular interest, is Androctonus australis hector (Aah ), one of the most toxic scorpions to humans, which is often implicated in fatal scorpion sting accidents in Algeria [2]. The venom of this scorpion contains numerous toxins, whose actions may have serious medical consequences following envenomation [1, 3]. Included amongst these toxins are the scorpion α toxins, which bind to voltage-gated sodium channels, causing prolonged depolarization, and neuronal excitation [4].…”
Section: Introductionmentioning
confidence: 99%
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“…Of particular interest, is Androctonus australis hector (Aah ), one of the most toxic scorpions to humans, which is often implicated in fatal scorpion sting accidents in Algeria [2]. The venom of this scorpion contains numerous toxins, whose actions may have serious medical consequences following envenomation [1, 3]. Included amongst these toxins are the scorpion α toxins, which bind to voltage-gated sodium channels, causing prolonged depolarization, and neuronal excitation [4].…”
Section: Introductionmentioning
confidence: 99%
“…Included amongst these toxins are the scorpion α toxins, which bind to voltage-gated sodium channels, causing prolonged depolarization, and neuronal excitation [4]. Both the sympathetic and parasympathetic nervous system is stimulated by these neurotoxins, resulting in the release of catecholamines and other vasoactive peptides, as well as hypertension, cardiac dysfunction and pulmonary edema, amongst other symptoms [1, 3]. An inflammatory response is observed, which causes metabolic derangements and organ damage [3].…”
Section: Introductionmentioning
confidence: 99%
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“…AKI most often occurs from envenoming by several mechanisms including: pigment nephropathy, interstitial nephritis, rhabdomyolysis or intravascular hemolysis, vasculitis or direct toxin effect but renal failure following scorpion stings is very rare and has been reported mainly in the Middle East, Eastern Mediterranean region and North Africa (Angsanakul and Sitprija., 2013;Sitprija and Sitprija., 2012;Viswanatham and Prabhu., 2011).…”
Section: Discussionmentioning
confidence: 99%
“…AKI after scorpion stings, can also be caused by inflammatory reactions due to proinflammatory cytokines (TNF alpha, IL 1 Beta, IL 6) and another mediators (Angsanakul and Sitprija, 2013;Petricevich, 2010).…”
Section: Discussionmentioning
confidence: 99%