2018
DOI: 10.1177/2156587217751796
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Scorpion Venom Causes Apoptosis by Increasing Reactive Oxygen Species and Cell Cycle Arrest in MDA-MB-231 and HCT-8 Cancer Cell Lines

Abstract: Scorpion venom induces apoptosis in breast and colorectal cell lines as reflected by the changes in the cell morphology and cell cycle studies. Furthermore, a high percentage of total reactive oxygen species as well as apoptotic cells also contribute to cell death as observed after venom treatments. To the best of authors' knowledge, this is the first scientific evidence demonstrating the induction of apoptosis and cell cycle arrest by these species of scorpion venoms.

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Cited by 20 publications
(21 citation statements)
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References 37 publications
(53 reference statements)
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“…The results of our study showed that fraction B obtained from Conus textile was able to increase the level of ROS in CLL. These results are in agreement with the results of previous studies that have shown that crude venom of Conus textile and other animal venoms have the ability to increase the level of ROS (Al-Asmari et al, 2018;Salimi et al, 2020).…”
Section: Fraction B Increased Ros Generation In Cll Blymphocytessupporting
confidence: 93%
“…The results of our study showed that fraction B obtained from Conus textile was able to increase the level of ROS in CLL. These results are in agreement with the results of previous studies that have shown that crude venom of Conus textile and other animal venoms have the ability to increase the level of ROS (Al-Asmari et al, 2018;Salimi et al, 2020).…”
Section: Fraction B Increased Ros Generation In Cll Blymphocytessupporting
confidence: 93%
“…One of the mechanisms of death induced by scorpion venoms is via caspases, the beneficial pathways in cancer therapy, as seen in our results, corroborating with the studies of other researchers who challenged different tumor cell lines, including leukemic cells when treated with the venom of the scorpion Heterometrus bengalensis Koch [31], cervical cancer cells ( Rhopalurus junceus ) [28], and prostate cancer cells ( Androctonus amoreuxi ) (Akef et al 2017). These results were also seen by Al-Asmari et al [32], where venoms of the scorpions Androctonus crassicauda, Androctonus bicolor, and Leiurus quinquestriatus also induced a death via apoptosis. Therefore, based on these findings and other published studies, a conclusion can be drawn that scorpion venom possesses cytotoxic and apoptotic properties against cervical cancer cell lines.…”
Section: Discussionsupporting
confidence: 79%
“…Many studies reported some physiological effects of the Chinese scorpion BmK venom known for its antiepileptic, analgesic, and, recently, antitumor properties. The use of this Chinese scorpion BmK venom revealed apoptogenic, immunosuppressive, and antiproliferative properties and demonstrated the potential of the cocktail for cancer-related diseases (Zhao et al, 2011; Li et al, 2014; Al-Asmari et al, 2016, 2018; Guo et al, 2016; Liu et al, 2017). The antitumor effect of the BmK venom was later accredited to an analgesic peptide called BmK AGAP and others (Zhao et al, 2011; Guo et al, 2016).…”
Section: Introductionmentioning
confidence: 99%