Key Points
Question
Are experiences of racial discrimination associated with altered resting-state connectivity patterns of salience network nodes?
Findings
In this cross-sectional study of 102 Black adults, more experiences of racial discrimination were associated with altered connectivity of the amygdala and anterior insula, even after adjusting for annual household income, lifetime trauma exposure, and current posttraumatic stress disorder symptoms.
Meaning
These findings suggest that experiencing racial discrimination is associated with modifications to known neural correlates of vigilance, suggesting a viable mechanism by which racism negatively affects mental health.