Scopolin obtained from Smilax china L. against hepatocellular carcinoma by inhibiting glycolysis: A network pharmacology and experimental study

Wang, Chen; Zhou, Qin; Wu, Songtao

doi:10.1016/j.jep.2022.115469

Cited by 12 publications

(7 citation statements)

References 48 publications

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“…Knockdown of GPI has been shown to severely impair glycolysis in cancer cells without affecting overall cell survival 26 . And regulation of glycolytic proteins like GPI has anti-tumor effects and may be a potential target for tumor treatment 27 28 . As well, GPI is implicated in the prognosis of cancer.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Plasma GPI and PGD are associated with vascular normalization and may serve as novel prognostic biomarkers for lung adenocarcinoma: Multi-omics and multi-dimensional analysis

Liu,

Wang,

Mao

et al. 2023

Preprint

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BackgroundThe aim of this study was to explore potentially novel plasma protein biomarkers for lung adenocarcinoma (LUAD).MethodsA plasma proteomics analysis was carried out in LUAD cases and healthy controls. Candidate protein biomarkers were validated in 102 LUAD cases and 102 matched healthy controls. The same LUAD tumor tissues were detected to explore the correlation between the expression of candidate proteins in tissues and plasma and vascular normalization. A LUAD active metastasis mice model was constructed to explore the role of candidate proteins for lung metastasis.ResultsIn the screening phase, 5 candidate proteins were selected. In the validation phase, GPI and PGD were verified to be upregulated in plasma from LUAD patients. The expression of GPI in tumor tissue was positively correlated with the expression of GPI in plasma and negatively correlated with the normalization of tumor blood vessels. Meanwhile, a negative correlation between the expression of GPI and PGD in plasma and tumor vascular normalization was discovered. In the LUAD active metastasis model, the lowest levels of vascular normalization and the highest expression of GPI and PGD were found in mice with lung metastasesConclusionThis study found that GPI and PGD may be potential diagnostic plasma biomarkers for LUAD, providing new clues to assist in LUAD early screening. Meanwhile, monitoring the concentration of GPI and PGD in plasma may reflect the level of vascular normalization within the tumor and infer the risk of metastasis and malignancy of the tumor.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Plasma GPI and PGD are associated with vascular normalization and may serve as novel prognostic biomarkers for lung adenocarcinoma: Multi-omics and multi-dimensional analysis

Liu,

Wang,

Mao

et al. 2023

Preprint

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“…The pentose phosphate pathway proteins play a vital role in mitigating various stresses by contributing to redox balance, nucleotide synthesis, secondary metabolite production, and overall cellular adaptation. GPI is involved in glycolysis and Calvin cycle, which is a critical pathway for energy production in plants (Wang et al, 2022). Under low P conditions, plants may adjust their energy metabolism to optimize ATP production and utilization.…”

Section: Discussionmentioning

confidence: 99%

Analysis of physiological response and differential protein expression of Paramichelia baillonii saplings under phosphorus deficiency

Ali,

Wu,

Chen

et al. 2024

Physiologia Plantarum

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Paramichelia baillonii is a rare and fast‐growing tree species in subtropical China. The acidic red soil in southern China severely limits its growth as it lacks sufficient available phosphorus (P), resulting in declining soil fertility and nutrient availability. The effect of P deficiency on P. Baillonii growth, root attributes, and physiological response has not yet been reported. Understanding the adaptability of P. baillonii to low‐P conditions can improve afforestation and soil management in southern China. Therefore, we conducted a pot experiment on 2‐year‐old saplings and treated them with different P levels. Results showed that P deficiency (0–5 mg L−1) decreased growth attributes, root morphological traits, and nutrient uptake of P. baillonii saplings compared to control (CK). Similarly, reduction in chlorophyll a, b, total chlorophyll, net photosynthetic rate (Pn), transpiration rate (Tr), and Gs were seen in low P treatment saplings compared to CK. Whereas superoxide dismutase, peroxidase, malondialdehyde, acid phosphatase activity, and soluble protein content increased with increasing P‐deficiency up to 5 mg L−1, and soluble sugar showed oppsite trend. Moreover, the proteomics analysis identified 2721 proteins, 196 showing differential expression, with 90 up‐ and 106 down‐regulated. Importantly, the metabolic activities increased in the pentose phosphate pathway, starch and sucrose metabolism, amino sugar and nucleotide sugar metabolism, and phenylpropanoid biosynthesis pathways to sustain regular plant growth under P deficiency. This study delves into the dynamic morpho‐physiological and proteomic changes in response to P deficiency. Overall, growth and nutrient uptake were reduced, countered by adaptive biochemical and proteomic shifts, including heightened antioxidant activities and modifications in metabolic pathways, highlighting the resilient strategies of P. baillonii saplings under P deficiency.

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“…a -Hederin, a potent bioactive compound of Pulsatilla chinensis (Bunge) Regel (Ranunculaceae), inhibited glucose uptake and ATP generation; and reduced lactate production by activating SIRT6 in A549 cells ( Fang et al, 2021a ). Scopolin obtained from Smilax china L. plays the role in controlling hepatocellular carcinoma by regulating the expression of glycolysis proteins glucose-6-phosphate isomerase (GPI), GPD2, mitochondrial and phosphoglycerate kinase 2 (PGK2) and affecting the interaction between Hsp90α and GPD2, which may provide a novel potential treatment direction for hepatocellular carcinoma ( Wang et al, 2022 ). GAPDH exerts metabolic flux control during aerobic glycolysis and therefore is an attractive therapeutic target for cancer.…”

Section: Natural Products Targeting Glycolysis In Cancermentioning

confidence: 99%

“…Dauricine, an isoquinoline alkaloid, downregulates the expression of HK2 and PKM2 in hepatocellular carcinoma cells ( Li W. et al, 2018 ). Scopolin inhibits glycolysis by inhibiting PGK2, GPI and GPD2 in hepatocellular carcinoma ( Wang et al, 2022 ). Berberine decelerates glucose metabolism via suppression of mTOR-dependent HIF-1α protein synthesis in colon cancer cells ( Mao et al, 2018a ).…”

Section: Natural Products Targeting Glycolysis In Cancermentioning

confidence: 99%

Natural products targeting glycolysis in cancer

et al. 2022

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Many energy metabolism pathways exist in cancer, including glycolysis, amino acid metabolism, fatty acid oxidation, and mitochondrial respiration. Tumor cells mainly generate energy through glycolysis to maintain growth and biosynthesis of tumor cells under aerobic conditions. Natural products regulate many steps in glycolysis and targeting glycolysis using natural products is a promising approach to cancer treatment. In this review, we exemplify the relationship between glycolysis and tumors, demonstrate the natural products that have been discovered to target glycolysis for cancer treatment and clarify the mechanisms involved in their actions. Natural products, such as resveratrol mostly found in red grape skin, licochalcone A derived from root of Glycyrrhiza inflate, and brusatol found in Brucea javanica and Brucea mollis, largely derived from plant or animal material, can affect glycolysis pathways in cancer by targeting glycolytic enzymes and related proteins, oncogenes, and numerous glycolytic signal proteins. Knowledge of how natural products regulate aerobic glycolysis will help illuminate the mechanisms by which these products can be used as therapeutics to inhibit cancer cell growth and regulate cellular metabolism.Systematic Review Registration: https://pubmed.ncbi.nlm.nih.gov/, https://clinicaltrials.gov/, http://lib.zzu.edu.cn/

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Scopolin obtained from Smilax china L. against hepatocellular carcinoma by inhibiting glycolysis: A network pharmacology and experimental study

Cited by 12 publications

References 48 publications

WITHDRAWN: Plasma GPI and PGD are associated with vascular normalization and may serve as novel prognostic biomarkers for lung adenocarcinoma: Multi-omics and multi-dimensional analysis

WITHDRAWN: Plasma GPI and PGD are associated with vascular normalization and may serve as novel prognostic biomarkers for lung adenocarcinoma: Multi-omics and multi-dimensional analysis

Analysis of physiological response and differential protein expression of Paramichelia baillonii saplings under phosphorus deficiency

Natural products targeting glycolysis in cancer

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