Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK–SREBP pathway in diet-induced obese mice

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract

“…Furthermore, as an axis of energy metabolism, AMPK activation counteracts oxidative stress by inhibiting NAD(P)H oxidase-derived ROS accumulation (43). Via activation of the AMPK-sterol regulatory element-binding protein signaling pathway, the levels of SOD and GSH-Px in the liver are enhanced (44). The results of the present study suggested that the antifatigue and antihypoxic effects of PHC treatment were predominantly through modulation of the AMPK pathway.…”

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

“…These antioxidant agents include natural antioxidants [e.g., vitamin C, E, coenzyme Q10, alpha-lipoic acid, fish oil containing n-3 fatty acids, betaine, and S-adenosyl-methionine (SAMe)], L-arginine, small-molecule metabolites (e.g., GSH-ethyl ester and NAC), and plants polyphenols (silimarin in milk thistle, curcumin, esculetin, sulforaphane, resveratrol, quercetin, epigallocatechin-3-gallate, caffeic acid phenethyl ester, and many others) (Andringa et al, 2010;Bailey et al, 2006;Cao et al, 2013;Cederbaum, 2010;Choi et al, 2013;Chung et al, 2012;Esfandiari et al, 2007;Ji & Kaplowitz, 2003;Kharbanda et al, 2012;Kim, Nagy, et al, 2014;Kim, Quon, & Kim, 2014;Lee, Mcgregor, et al, 2013;Lee, Yun, Seo, Kim, & Lee, 2014;Lieber, 2002;Marcolin et al, 2012;Nanji et al, 2003;Powell et al, 2010;Rodrigues et al, 2013;Scorletti et al, 2014;Shin et al, 2014;Song, et al, 2008;Surapaneni et al, 2014). These antioxidants, contained in many fruits and vegetables, show beneficial effects on AFLD, NAFLD, and DILI, although some of these antioxidants also exhibit significant protection in other tissues such as heart, muscle, and brain (Pallauf, Giller, Huebbe, & Rimbach, 2013;Rodriguez et al, 2015).…”

Coordinated regulation of scopoletin at adipose tissue–liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats

“…Scopoletin possesses a wide range of biological activities, such as anti-inflammatory effects, antioxidant and anti-diabetic activity (Everitt et al, 2013;Mogana et al, 2013). In our previous study, scopoletin prevented alcoholinduced hepatic lipid accumulation in diet-induced obese mice (Lee et al, 2014). However, it is still not known whether scopoletin can regulate alcoholic hepatosteatosis and its molecular mechanism at the WAT-liver axis.…”