Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Plakke, Bethany; Ng, Chi-Wing; Poremba, Amy

doi:10.1016/j.neulet.2008.04.015

Cited by 20 publications

(16 citation statements)

References 38 publications

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“…One likely possibility is through effects on food motivational or consummatory processes. While the effects of systemic scopolamine administration on food motivation are mixed (Khokhlova et al 2001; Plakke et al 2008), scopolamine infused directly into the nucleus accumbens is reported to decrease food consumption (Perry et al 2010; Pratt and Blackstone 2009). Such an effect is consistent with the increase in trial omissions produced by both muscarinic antagonists (i.e., reductions in food motivation via prefeeding have similar effects in these and other choice tasks; Simon et al 2009; St.…”

Section: Discussionmentioning

confidence: 99%

Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost–benefit decision making tasks in rats

et al. 2012

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Rationale Alterations in cost–benefit decision making accompany numerous neuropsychiatric conditions, including schizophrenia, attention deficit hyperactivity disorder, and addiction. Central cholinergic systems have been linked to the etiology and/or treatment of many of these conditions, but little is known about the role of cholinergic signaling in cost–benefit decision making. Objectives The goal of these experiments was to determine how cholinergic signaling is involved in cost–benefit decision making, using a behavioral pharmacological approach. Methods Male Long-Evans rats were trained in either “probability discounting” or “delay discounting” tasks, in which rats made discrete-trial choices between a small food reward and a large food reward associated with either varying probabilities of omission or varying delays to delivery, respectively. The effects of acute administration of different doses of nicotinic and muscarinic acetylcholine receptor agonists and antagonists were assessed in each task. Results In the probability discounting task, acute nicotine administration (1.0 mg/kg) significantly increased choice of the large risky reward, and control experiments suggested that this was due to robust nicotine-induced impairments in behavioral flexibility. In the delay discounting task, the muscarinic antagonists scopolamine (0.03, 0.1, and 0.3 mg/kg) and atropine (0.3 mg/kg) both significantly increased choice of the small immediate reward. Neither mecamylamine nor oxotremorine produced reliable effects on either of the decision making tasks. Conclusions These data suggest that cholinergic receptors play multiple roles in decision making contexts which include consideration of reward delay or probability. These roles should be considered when targeting these receptors for therapeutic purposes.

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Section: Discussionmentioning

confidence: 99%

Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost–benefit decision making tasks in rats

et al. 2012

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“…Baseline firing rate has been subtracted from each curve. (Chudasama et al 2004;Penetar and McDonough 1983;Plakke et al 2008;Taffe et al 1999;Yamamoto et al 2011). If, however, accuracy at zero-delay length trials is also compared with variable longer delays, an effect of delay length is found (Buccafusco et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Cholinergic modulation of working memory activity in primate prefrontal cortex

Zhou

Douglas

et al. 2011

Journal of Neurophysiology

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DT, Constantinidis C. Cholinergic modulation of working memory activity in primate prefrontal cortex. J Neurophysiol 106: 2180-2188. First published July 27, 2011 doi:10.1152/jn.00148.2011The prefrontal cortex, a cortical area essential for working memory and higher cognitive functions, is modulated by a number of neurotransmitter systems, including acetylcholine; however, the impact of cholinergic transmission on prefrontal activity is not well understood. We relied on systemic administration of a muscarinic receptor antagonist, scopolamine, to investigate the role of acetylcholine on primate prefrontal neuronal activity during execution of working memory tasks and recorded neuronal activity with chronic electrode arrays and single electrodes. Our results indicated a dose-dependent decrease in behavioral performance after scopolamine administration in all the working memory tasks we tested. The effect could not be accounted for by deficits in visual processing, eye movement responses, or attention, because the animals performed a visually guided saccade task virtually error free, and errors to distracting stimuli were not increased. Performance degradation under scopolamine was accompanied by decreased firing rate of the same cortical sites during the delay period of the task and decreased selectivity for the spatial location of the stimuli. These results demonstrate that muscarinic blockade impairs performance in working memory tasks and prefrontal activity mediating working memory.

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“…The experiments were carried out between January 2008 and August 2010 at the University of Iowa. Both monkeys had prior experience with similar auditory DMTS tasks [Ng et al., ; Plakke et al., ]. The animals were housed in individual cages on a 12:12 h light/dark cycle with ad libitum access to water and controlled feeding schedules.…”

Section: Methodsmentioning

confidence: 99%

Auditory Memory in Monkeys: Costs and Benefits of Proactive Interference

Bigelow

Poremba

2012

American J Primatol

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Proactive interference (PI) has traditionally been understood as an adverse consequence of stimulus repetition during memory tasks. Herein, we present data that emphasize costs as well as benefits of PI for monkeys performing an auditory delayed matching-to-sample (DMTS) task. The animals made same/different judgments for a variety of simple and complex sounds separated by a 5-s memory delay. Each session used a stimulus set that included eight sounds; thus, each sound was repeated multiple times per session for match trials and for nonmatch trials as the sample (Cue 1) or test (Cue 2) stimulus. For nonmatch trials, performance was substantially diminished when the test stimulus had been previously presented on a recent trial. However, when the sample stimulus had been recently presented, performance was significantly improved. We also observed a marginal performance benefit when stimuli for match trials had been recently presented. The costs of PI for nonmatch test stimuli were greater than the combined benefits of PI for nonmatch sample stimuli and match trials, indicating that the net influence of PI is detrimental. For all three manifestations of PI, the effects are shown to extend beyond the immediately subsequent trial. Our data suggest that PI in auditory DMTS is best understood as an enduring influence that can be both detrimental and beneficial to memory-task performance.

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Scopolamine impairs auditory delayed matching-to-sample performance in monkeys

Cited by 20 publications

References 38 publications

Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost–benefit decision making tasks in rats

Effects of acute administration of nicotinic and muscarinic cholinergic agonists and antagonists on performance in different cost–benefit decision making tasks in rats

Cholinergic modulation of working memory activity in primate prefrontal cortex

Auditory Memory in Monkeys: Costs and Benefits of Proactive Interference

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