Scoping review of chronic rhinosinusitis proteomics

Kao, Stephen Shih-Teng; Bassiouni, Ahmed; Ramezanpour, Mahnaz; Chegeni, Nusha; Colella, Alex D.; Chataway, Tim; Wormald, Peter‐John; Vreugde, Sarah; Psaltis, Alkis James

doi:10.4193/rhin20.034

Cited by 14 publications

(20 citation statements)

References 25 publications

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“…Systems biology has provided a more holistic understanding of diseases and endotypes [81][82][83] . Proteomic analysis of nasal mucus and mucosa in CRS suggested a trend of increased presence of immunological, metabolic, tissue remodeling and apoptotic pathways in CRS 84,85 . Metabolomics analysis of low molecular weight compounds (up to 1,500 Da) has been performed in CRS 83 .…”

Section: Genomics Proteomics and Metabolomicsmentioning

confidence: 99%

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Kato¹,

Peters²,

Stevens³

et al. 2021

Preprint

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Chronic rhinosinusitis (CRS) is a common clinical syndrome that produces significant morbidity and costs to our health system. The study of CRS has progressed from an era focused on phenotype to include endotype based information. Phenotypic classification has identified clinical heterogeneity in CRS based on endoscopically observed features such as presence of nasal polyps, presence of comorbid or systemic diseases and timing of disease onset. More recently, laboratory-based findings have established CRS endotype based upon specific mechanisms or molecular biomarkers. Understanding the basis of widespread heterogeneity in the manifestations of CRS is advanced by findings that the three main endotypes, Type 1, 2 and 3, orchestrate the expression of three distinct large sets of genes. The development and use of improved methods of endotyping disease in the clinic is ushering in an expansion of the use of biological therapies targeting Type 2 inflammation now and perhaps other inflammatory endotypes in the near future. The purpose of this review is to discuss the phenotypic and endotypic heterogeneity of CRS from the perspective of advancing the understanding of the pathogenesis and improvement of treatment approaches and outcomes.

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Section: Genomics Proteomics and Metabolomicsmentioning

confidence: 99%

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Kato¹,

Peters²,

Stevens³

et al. 2021

Preprint

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show abstract

“…Gel electrophoresis is the most commonly used method for protein separation in mucus proteomic studies. 6 The recovery of proteins from gel is poor for highly glocosylated and sialidated and sulphated proteins. Alternative non-gel-based separation methods include various chromatography techniques.…”

Section: Limitationsmentioning

confidence: 99%

“…Despite these limitations, we were able to identify a comprehensive catalog of proteins correlating well with previously published literature. 6 Furthermore, minimal cytokines were identified by MS analysis within nasal mucus. Yoshikawa et al found MS to be insensitive for cytokines and growth factors on account of their small size and low abundance.…”

Section: Limitationsmentioning

confidence: 99%

“…A systematic review of the literature conducted in our department identified 21 studies investigating the proteome of nasal mucus and mucosa from healthy patients and patients with CRS. 6 Gene set enrichment analysis (GSEA) of the differentially expressed proteins identified increased immunologic, metabolic, and tissue remodeling pathways and processes present in patients with CRS compared with those in healthy patients. Notably, the most recent of these studies comparing the CRS and healthy proteome was published 8 years ago, 7 and since then there have been considerable advances in the speed, resolution, and, sensitivity of mass spectrometry (MS) equipment.…”

mentioning

confidence: 99%

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Proteomic analysis of nasal mucus samples of healthy patients and patients with chronic rhinosinusitis

Kao

Bassiouni

Ramezanpour

et al. 2021

Journal of Allergy and Clinical Immunology

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“…More recently, single cell gene expression studies have also revealed distinct populations of epithelial cells and lymphocytes uniquely contributing to CRS pathophysiology (117,118) . Transcriptional changes have largely been validated by proteomic studies (119)(120)(121) as well as cellular and histologic studies of sinonasal mucosa which have highlighted not only importance of inflammatory dysregulation, but tissue remodeling in CRS pathophysiology (122)(123)(124)(125)(126) .…”

Section: Recent Multiomic Approaches Applied To Crs Have Revealed Novel Insights Into the Pathophysiologic Mechanisms Of Crsmentioning

confidence: 99%

Rhinology in review: from COVID-19 to biologicals

Fokkens¹,

Landis²,

Hopkins³

et al. 2021

Rhin

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We look back at the end of what soon will be seen as an historic year, from COVID-19 to real-world introduction of biologicals influencing the life of our patients. This review describes the important findings in Rhinology over the past year. A large body of evidence now demonstrates loss of sense of smell to be one of the most common symptoms of COVID-19 infection; a meta-analysis of 3563 patients found the mean prevalence of self-reported loss to be 47%. A number of studies have now shown long-term reduced loss of smell and parosmia. Given the high numbers of people affected by COVID-19, even with the best reported recovery rates, a significant number worldwide will be left with severe olfactory dysfunction. The most prevalent causes for olfactory dysfunction, besides COVID-19 and upper respiratory tract infections in general, are trauma and CRSwNP. For these CRSwNP patients a bright future seems to be starting with the development of treatment with biologics. This year the Nobel prize in Medicine 2021 was awarded jointly to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch which has greatly enhanced our understanding of nasal hyperreactivity and understanding of intranasal trigeminal function. Finally, a new definition of chronic rhinitis has been proposed in the last year and we have seen many papers emphasizing the importance of endotyping patients in chronic rhinitis and rhinosinusitis in order to optimise treatment effect.

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Scoping review of chronic rhinosinusitis proteomics

Cited by 14 publications

References 25 publications

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Endotypes of Chronic Rhinosinusitis; relationships to disease phenotypes, pathogenesis, clinical findings and treatment approaches.

Proteomic analysis of nasal mucus samples of healthy patients and patients with chronic rhinosinusitis

Rhinology in review: from COVID-19 to biologicals

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