Sclerotherapy for Aneurysmal Bone Cyst: A Single-Center Experience

Kumar, Deepak; Kumar, Sanjeev; Kumar, Dharmendra; Patel, Brij Mohan; Kumar, Amit; Kumar, Santosh; Waliullah, Shah

doi:10.7759/cureus.18469

Cited by 8 publications

(11 citation statements)

References 28 publications

(41 reference statements)

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“…Sclerotherapy can cause damage the endothelium and consequently induce thrombosis of pathological small vessels leading to lesion healing, which makes it a treatment option for ABCs 5 25–27. Sclerotherapy provides a minimally invasive treatment so it is particularly useful for deep lesions, which are challenging for surgical access 26…”

Section: Discussionmentioning

confidence: 99%

Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child

Singh,

Madasswery,

Colman

et al. 2024

BMJ Case Rep

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Aneurysmal bone cyst (ABC) is a non-malignant, locally destructive, blood-filled lesion in the bone that tends to grow aggressively. A young girl presented with a rapid recurrence after aggressive surgery of a large symptomatic sacral-spinal ABC. After a multidisciplinary tumour board, she was successfully treated with sclerotherapy and monthly intravenous denosumab. The patient has maintained asymptomatic for over 36 months now and has returned to full activity and strength. She never required surgery and has had radiologic resolution of the lesions. Treatment of recurrent ABC requires a multidisciplinary team approach. We believe this to be the first report to use this combined therapy to provide an alternative to morbid surgery for children with ABCs.

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Section: Discussionmentioning

confidence: 99%

Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child

Singh,

Madasswery,

Colman

et al. 2024

BMJ Case Rep

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“…Therefore, sclerotherapy has provided an effective and minimally invasive treatment for ABC and is particularly useful for deep injuries, challenging access to surgery, and potentially injurious vital structures. The use of 3% percutaneous polidocanol under fluoroscopic control appeared to improve the risk/benefit ratio [26].…”

Section: Vol 3 Suppl 6 Year 2022mentioning

confidence: 99%

Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review

Vasconcelos¹,

Bannak²,

Naves³

et al. 2022

MedNEXT

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Introduction: Aneurysmal bone cysts (ABC) are pseudocysts expansive lesions. The World Health Organization (WHO) categorizes primary ABCs as cystic neoplasms that contain fibrous septa separating numerous blood-filled spaces. Approximately 70% of ABC cases are primary, while 30% are secondary. Objective: The present study aimed to carry out a concise systematic review of the main clinical findings of aneurysmal bone cysts, highlighting the incidence and prevalence, as well as the main forms of treatment. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from May 2022 to July 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results: A total of 143 articles were found. In total, 73 articles were evaluated and 10 were included and evaluated in the systematic review. The symmetric funnel plot does not suggest a risk of bias. After prospecting the main literary findings, it was generally evidenced that the aneurysmal bone cyst (ABC) is a rare lesion that is more frequently found in young adults and children. It may have unpredictable behavior, with a high recurrence rate after treatment. Standard treatment consists of curettage plus local adjuvants and bone grafting to fill the void. In anatomic sites with difficult surgical access, percutaneous procedures are used (injection of sclerosing agents, radiofrequency thermal ablation, or selective arterial embolization. Medical management with bisphosphonates or denosumab has also been advocated. Conclusion: Primary ABCs involving the maxillofacial region are extremely rare and even more in patients with advanced age. Next-generation sequencing confirmed the presence of a USP6-CDH11 fusion gene, consistent with classification as a primary aneurysmal bone cyst. Sclerotherapy provided an effective and minimally invasive treatment for aneurysmal bone cysts and is particularly useful for deep injuries, challenging surgical access, and potentially injurious vital structures.

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“…A comprehensive comprehension of these systems is essential for formulating precise therapies and therapeutic methods to alleviate the neurological repercussions of viral illnesses. Future research endeavors should persist in elucidating the complexities of these pathophysiological mechanisms, yielding vital understandings of the prevention and treatment of infectious disorders that impact the nervous system [ 53 ].…”

Section: Reviewmentioning

confidence: 99%

Neurological Manifestations of Infectious Diseases: Insights From Recent Cases

Kashyap,

Olanrewaju,

Mahar

et al. 2023

Cureus

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This narrative review examines the complex connection between infectious diseases and their neurological effects. It provides a detailed analysis of recent instances and insights derived from various pathogens. As we explore the realm of infectious agents, including viruses, bacteria, parasites, and fungi, a thorough and diverse analysis reveals the intricacies of neurological problems. The review begins by examining viral infections, specifically focusing on how viruses invade the neurological system and its subsequent effects. Significant instances from recent widespread disease outbreaks function as instructive benchmarks, highlighting the progressing comprehension of these ever-changing interconnections. The article examines the complex pathophysiology of neurological problems caused by bacterial infections. It presents current cases that illustrate the various ways these complications might manifest and the difficulties faced in their therapeutic management. Parasitic and fungal infections, which are typically overlooked, are being carefully examined to emphasize their distinct role in causing neurological complications. The mentioned cases highlight the importance of being thoroughly aware of these less-explored areas ranging from protozoan parasites to opportunistic fungal infections. In addition to the immediate effects caused by infectious agents, the review investigates autoimmune responses activated by infections. It provides a detailed examination of specific instances that shed light on the complex relationship between viral triggers and future neurological problems. This text elaborates on the intricacy of autoimmune-related neurological issues, highlighting the necessity for a comprehensive approach to diagnosing and treating them. The narrative next redirects its attention to the diagnostic difficulties that arise when interpreting the neurological symptoms of viral disorders. This article provides a thorough examination of existing diagnostic tools, along with an investigation into new technologies that have the potential to improve our capacity to identify and comprehend complex presentations. This debate connects to the following examination of treatment methods, where current cases that showcase successful interventions are carefully examined to extract valuable insights into good clinical management. The discussion focuses on the public health implications of preventive efforts against infectious infections, including their neurological consequences. The story emphasizes the link between infectious diseases and overall societal health, advocating for a proactive strategy to reduce the impact of neurological complications. The abstract concludes by providing a prospective viewpoint, highlighting areas of research that still need to be addressed, and suggesting potential future avenues. This narrative review seeks to provide a comprehensive resource for physicians, researchers, and public health professionals dealing with the complex field of neurological manifestations in infectious dise...

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Sclerotherapy for Aneurysmal Bone Cyst: A Single-Center Experience

Cited by 8 publications

References 28 publications

Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child

Denosumab and sclerotherapy for recurrent spinal aneurysmal bone cyst in a child

Incidence and major clinical approaches of aneurismatic bone cysts: a concise systematic review

Neurological Manifestations of Infectious Diseases: Insights From Recent Cases

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