Sclerostin serum levels in prostate cancer patients and their relationship with sex steroids

Abstract

Circulating sclerostin levels are significantly increased in patients with PC and particularly in those receiving ADT. The inverse relationship between serum sclerostin and testosterone in these patients suggests that androgens are key regulators of bone metabolism in this population.

Bone turnover markers in serum and urine as diagnostic, prognostic and monitoring biomarkers of bone metastasis

“…These data corrected the first report of the same working group that prostate cancer patients with and without bone metastases had increased values in comparison to healthy men [150]. There are some study results on serum values of sclerostin and DKK-1 in their relationships with age, sex hormones, bone mass, and conventional bone turnover markers in men and prostate cancer patients [44,47,48,151]. However, the current rather unclear state of scientific knowledge does not entitle the use of both analytes in clinical settings, but the inclusion in clinical studies with well-defined objectives seems to be meaningful.…”

Gender differences in sclerostin and clinical characteristics in type 1 diabetes mellitus

“…This hypothesis can be realistic after the study conducted by Amrein et al (24), in which men had significantly higher unadjusted sclerostin levels than women but levels were not significantly different after adjustment for skeletal size. Our data raise the issue of the role of sex steroids in explaining gender differences in sclerostin serum levels: both estrogen and testosterone are critical regulators of bone turnover and have been inversely associated with sclerostin levels (25,26). Disturbances in these …”

“…A reduced bone formation as a consequence of reduced osteoblast activity has been identified as the mean pathogenetic effect or for low bone mineral density (BMD) in subjects with T1DM (1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39). intimal thickening in atherosclerosis, and Wnt/b-catenin signaling is a regulator of VSMC behavior (9).…”

Sclerostin

“…This suggests a complex interplay of bone mass, mechanical loading, and bone turnover related to sex steroids. Serum sclerostin levels are significantly increased in patients with prostate cancer, particularly in those receiving androgen deprivation therapies [26,37], suggesting a mechanistic explanation for the role of androgens in bone metabolism in these patients.…”