Sclerostin and parathyroid hormone responses to acute whole-body vibration and resistance exercise in young women

Abstract

Whole-body vibration (WBV) has been shown to improve bone mineral density, and muscle strength and power. No studies to date have examined sclerostin and parathyroid hormone (PTH) responses to WBV combined with resistance exercise (RE). This randomized crossover study compared acute serum sclerostin and PTH responses to RE and WBV + RE in young women (n = 9) taking oral contraceptives. Participants were exposed to 5 1-min bouts of vibration (20 Hz, 3.38 peak-peak displacement, separated by 1 min of rest) before high intensity resistance exercise. Fasting blood samples were obtained before (PRE), immediately after WBV (POSTWBV), immediately post RE (IP) and 30 min post RE (30P). Pre-exercise sclerostin and PTH levels were not significantly different between conditions. Sclerostin levels significantly (p < 0.05) increased from PRE to IP for the WBV + RE condition, then decreased back to the pre-exercise level. PTH significantly decreased from PRE to 30P (p < 0.05) and IP to 30P (p < 0.01) for both conditions. Correcting for hemoconcentration eliminated the significant sclerostin responses, but the significant decrease in PTH remained (p < 0.05). There were no significant relationships found between sclerostin and PTH. In conclusion, sclerostin concentrations increased in response to the WBV + RE condition, which may have been mediated by plasma volume shifts. There was no transient PTH increase, but it showed a large decrease at 30P for both conditions. Based on these findings, the addition of WBV exposures prior to high intensity RE did not alter sclerostin and PTH responses to RE in young women.

Parathormone and Serum Calcium Response to Moderate Intensity Treadmill Exercise in Elderly

“…Moreover Falk et al, (21) reported mixed results that PTH levels were same in male adolescents and adult; at rest and during experiment, increasing considerably 5 minutes after activity, decreasing after 60 minutes post-exercise, and returning to resting values within 24 hours . The current study's findings were reinforced by Sharma-Ghimire et al, (22) who discovered that in young women, there was no transient increase in PTH in response to transient whole-body vibration and resistive training, but it did exhibit a significant drop after 30 minutes for both treatments. The mechanisms of PTH exercise reactivity are not really recognized, according to their study; which showed that the amount of PTH produced in response to acute physical stimuli varies based on the kind of exercise .…”

Acute Response of Sclerostin to Whole-body Vibration with Blood Flow Restriction

“…A transient increase in serum sclerostin has been reported following an acute bout of WBV [22], combined resistance training with WBV [23], physical activity [18,19], high-intensity interval exercise [20], and jumping [21]. One study found a lack of change in sclerostin immediately following five 1-minute bouts of WBV (20 Hz, 3.38 mm, ~2.7 g) [23], whereas another study reported a 91 % increase in plasma sclerostin from pre-to 10 minutes post-WBV (40 Hz, 2 mm, ~2.7 g) [22]. The contrast in findings may be attributed to the differences in the time point analyses or factors relating to the vibration stimulus.…”

“…One potentially important mechanism by which mechanical stimuli influence osteocyte activity is through regulating sclerostin, an osteocyte-derived secreted glycoprotein, which inhibits bone formation through inhibition of the Wnt/β-catenin pathway [16,17]. There have been few human studies to date reporting the response of sclerostin to acute exercise, although current evidence suggests that sclerostin levels increase following an acute bout of physical activity [18,19], high-intensity interval exercise [20], jumping [21], whole-body vibration (WBV) [22], and combined high-intensity resistance training and WBV [23].…”

Sclerostin - a potential new marker of exercise influence on vascular calcification and mineral and bone disorder in hemodialysed adults

“…Császárné Gombos et al shown that serum sclerostin concentrations increased in participants in the resistance exercise group and walking group compared to its base level [29]. Additionally, the study of Falk et al, in which blood samples were taken after plyometric exercises and the study of Sharma-Ghimire et al, in young women researched response to the whole-body vibration and high intensity resistance exercise also came to the conclusion that sclerostin concentrations increased after acute exercise [30,31]. When considering studies depicting acute exercise one must notice that those studies most often don't include long term variability.…”