Abstract:CONTEXT: Thecomas are benign tumors that account for less than 1% of all ovarian neoplasms. The association of ovarian thecoma with sclerosing peritonitis is rare.
CASE REPORT:We report the case of a 33-yearold woman, with a two-month history of increasing abdominal volume. Ultrasound showed a complex pelvic lesion and laboratory analysis detected elevated serum CA 125 levels. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and peritoneal biopsy. Histopathological analys… Show more
“…8). Since then, only a limited number of cases have been reported in the literature mostly as case reports [143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158][159][160][161][162] with only one large series of 27 patients providing a comprehensive clinical, morphological, and immunohistochemical characterization of these lesions. 64 Although the term "luteinized thecomas" has prevailed in the literature, it is now favored by some that these are not neoplastic proliferations as they cause an expansion of the ovarian cortex with entrapment of preexisting structures, a feature not typically seen in neoplastic processes, and thus, the alternative term of thecomatosis has been proposed to denote its possible non-neoplastic nature.…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
confidence: 99%
“…Some patients have had a prior history of anticonvulsant or propranolol therapy or autoimmune disease, 64,150,151 and a few elevated CA-125 serum levels. 153 Rarely extraperitoneal involvement has been described including cutaneous 165 and extraperitoneal lesions. 148 Patients suffer from complications related to their peritoneal disease, most often bowel obstruction that in the past resulted in high morbidity and up to 30% mortality; symptoms may develop after the resection of ovarian lesions and may persist for months.…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
confidence: 99%
“…Hormonal manifestations are rare. Some patients have had a prior history of anticonvulsant or propranolol therapy or autoimmune disease, 64,150,151 and a few elevated CA-125 serum levels 153 . Rarely extraperitoneal involvement has been described including cutaneous 165 and extraperitoneal lesions 148 .…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
In two separate reviews, we reviews the time-honored but still frequently challenging features of ovarian sex cord–stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E. Scully. In part I, we present the major clinical, pathologic, and genomic features of the pure ovarian stromal tumors including comments on differential diagnosis and briefly note significant historical contributions. In part II we will discuss pure sex cord and sex cord–stromal tumors.
“…8). Since then, only a limited number of cases have been reported in the literature mostly as case reports [143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158][159][160][161][162] with only one large series of 27 patients providing a comprehensive clinical, morphological, and immunohistochemical characterization of these lesions. 64 Although the term "luteinized thecomas" has prevailed in the literature, it is now favored by some that these are not neoplastic proliferations as they cause an expansion of the ovarian cortex with entrapment of preexisting structures, a feature not typically seen in neoplastic processes, and thus, the alternative term of thecomatosis has been proposed to denote its possible non-neoplastic nature.…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
confidence: 99%
“…Some patients have had a prior history of anticonvulsant or propranolol therapy or autoimmune disease, 64,150,151 and a few elevated CA-125 serum levels. 153 Rarely extraperitoneal involvement has been described including cutaneous 165 and extraperitoneal lesions. 148 Patients suffer from complications related to their peritoneal disease, most often bowel obstruction that in the past resulted in high morbidity and up to 30% mortality; symptoms may develop after the resection of ovarian lesions and may persist for months.…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
confidence: 99%
“…Hormonal manifestations are rare. Some patients have had a prior history of anticonvulsant or propranolol therapy or autoimmune disease, 64,150,151 and a few elevated CA-125 serum levels 153 . Rarely extraperitoneal involvement has been described including cutaneous 165 and extraperitoneal lesions 148 .…”
Section: Luteinized Thecoma With Sclerosing Peritonitismentioning
In two separate reviews, we reviews the time-honored but still frequently challenging features of ovarian sex cord–stromal tumors, and also emphasize new developments including unusual morphologic appearances that, despite the relative rarity of many of the tumors, result in a disproportionate number of differential diagnostic problems, variant immunohistochemical profiles, and specific molecular and syndromic associations. These neoplasms are also of historical interest as current knowledge is still based in significant part on the contributions of 2 giants of gynecologic pathology, Dr Robert Meyer and Dr Robert E. Scully. In part I, we present the major clinical, pathologic, and genomic features of the pure ovarian stromal tumors including comments on differential diagnosis and briefly note significant historical contributions. In part II we will discuss pure sex cord and sex cord–stromal tumors.
“…SP is a benign condition but patients may develop ascites, abdominal pain, or small bowel obstruction (5,6). Recurrent small bowel obstruction and surgical complications can cause significant morbidity and are potentially fatal (5)(6)(7)(8)(9)(10)(11).…”
Sclerosing peritonitis is an uncommon condition that has been reported in patients with luteinized ovarian thecomas, although some pathologists have suggested that the underlying ovarian pathology is not always neoplastic. We now report sclerosing peritonitis in a patient with an uncommon, luteinized variant of an adult granulosa cell tumor. To the best of our knowledge, this association has not been described previously. We suggest that sclerosing peritonitis may result from the release of substances by luteinized ovarian stromal cells, in the context of hyperplasia or neoplasia, which stimulate the proliferation of submesothelial fibroblasts.
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