Sclerosing Peritonitis Associated With a Luteinized Adult Granulosa Cell Tumor

Abstract

Sclerosing peritonitis is an uncommon condition that has been reported in patients with luteinized ovarian thecomas, although some pathologists have suggested that the underlying ovarian pathology is not always neoplastic. We now report sclerosing peritonitis in a patient with an uncommon, luteinized variant of an adult granulosa cell tumor. To the best of our knowledge, this association has not been described previously. We suggest that sclerosing peritonitis may result from the release of substances by luteinized ovarian stromal cells, in the context of hyperplasia or neoplasia, which stimulate the proliferation of submesothelial fibroblasts.

The Multifaceted Granulosa Cell Tumours—Myths and Realities: A Review

“…The most common pair of synchronous lesions involves the endometrium and the ovary [40]. GCTs have been reported in coexistence with a number of pathologies including mucinous cystadenoma [7, 41, 42], cystic teratoma [7], ovarian fibroma [43], ovarian angiosarcoma, adenosarcoma, cystadenosarcoma [44], sclerosing peritonitis [45], gastric signet-ring cell carcinoma [46], and cervical lipoleiomyoma [47]. In the indexed case 4 GCT was found to coexist with colonic adenocarcinoma as a unique collision tumor which has been discussed previously in detail [48].…”