Sclerosing lipogranuloma of the male genitalia containing vitamin E: A comparison with classical “paraffinoma”

Adverse cutaneous reactions to soft tissue fillers – a review of the histological features

“…1). A similar finding occurs following the injection of oily materials of similar chemical structure, such as sheep lanolin, Vaseline and vitamin E 38,39 …”

Adverse reactions to injectable soft tissue fillers

“…Moreover, accidental injections of paraffin and other mineral oils, such as sheep lanolin, petroleum jelly, and vitamin E, can still be seen today, and patients with psychiatric or personality disorders may be capable of injecting themselves with a wide variety of substances. A specific form of paraffinoma is the so-called sclerosing lipogranuloma, which results from injection of paraffin in the penis causing fibrosis and deformity of the penis body 143,145,148,150,151,154,156,158,161,162 (Fig 12). The involved areas of paraffinoma appear as erythematous indurated plaques and in rare instances the lesion may ulcerate the overlying epidermis, mimicking a squamous cell carcinoma.…”

Sclerosing Lipogranuloma Seconda y to Supposed Vitamin E Injection for Facial Rejuvenation: Successful Treatment with Intralesional Steroids

“…In this patient, an inflammatory response was noted with in the first week after the injections. Vitamin E, a mixture of toco‐pheryl acetate, tocopherol, and triglycerides, 9 has rarely reported in the literature as a cause of paraffinoma. Foucar et al 9 reported a case in which topical application of vitamin E produced a sclerosing lipogranuloma on genital skin.…”

“…Vitamin E, a mixture of toco‐pheryl acetate, tocopherol, and triglycerides, 9 has rarely reported in the literature as a cause of paraffinoma. Foucar et al 9 reported a case in which topical application of vitamin E produced a sclerosing lipogranuloma on genital skin. No history of local injections could be obtained, but tissue lipid analysis demonstrated large quantities of tocopherol and tocopheryl acetate.…”