Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy

Lee, Vickie; Bentley, Christopher; Olver, Jane

doi:10.1038/eye.1998.83

Cited by 47 publications

(27 citation statements)

References 16 publications

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“…Predictive factors for ocular complications caused by anticancer drug S-1 69 subepithelial nerves, and dysplasia and fibrosis of conjunctival cells [17][18][19][20][21][22]. In this study, patients in the positive group, showing side-effects of S-1 chemotherapy, were significantly older than those in the negative group, who developed not sideeffects.…”

Section: Discussionmentioning

confidence: 89%

Predictive factors for ocular complications caused by anticancer drug S-1

et al. 2016

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Section: Discussionmentioning

confidence: 89%

Predictive factors for ocular complications caused by anticancer drug S-1

et al. 2016

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“…7 Epiphora resulting from permanent lacrimal gland stenosis has been reported in patients receiving combination chemotherapy of cyclophosphamide, methotrexate and 5-fluorouracil. 12,13 Excessive tearing that resolves on cessation of treatment is commonly described as a side effect of 5-fluorouracil. 13 Alopecia, trichomegally and hypertrichosis have been reported as side effects of interferon therapy.…”

Section: Ocular Adnexia Side Effectsmentioning

confidence: 99%

“…12,13 Excessive tearing that resolves on cessation of treatment is commonly described as a side effect of 5-fluorouracil. 13 Alopecia, trichomegally and hypertrichosis have been reported as side effects of interferon therapy. 14,15 In rare cases, the severity of these side effects may require interruption of therapy.…”

Section: Ocular Adnexia Side Effectsmentioning

confidence: 99%

Toxicidad ocular de la quimioterapia sistémica anticancerosa

Omoti

2006

Pharmacy pract. (Granada Ed. impr.)

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*The increased use of chemotherapeutic agents has resulted in longer cancer patient survival. Consequently the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Ocular toxicity induced by cancer chemotherapy includes a broad spectrum of disorders, reflecting the unique anatomical, physiological and biochemical features of the eye. Understanding the ocular side effects will assist the ophthalmologist and oncologist to recognize them early and intervene before blindness occurs. Anticipation of various treatmentrelated toxicities may also provide the opportunity for pharmacists to develop intervention strategies that could minimize or eliminate an expected side effect. The ophthalmologist should examine patients on anticancer therapy at baseline and three monthly thereafter. The various ocular side effects of anticancer chemotherapeutic agents, tamoxifen, and interferon on the adnexia, anterior segment, posterior segment and neuro-ophthalmic structures were reviewed.

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“…11 Evaluation of a biopsy specimen of the canaliculi of another patient with epiphora secondary to treatment with 5-FU revealed fibrosis of the punctum. 12 Another FIG. 3. A, Cross section of nasal mucosa in patient 2 reveals marked keratinization of surface epithelium (arrow) with parakeratosis and hyperkeratosis.…”

mentioning

confidence: 97%