Scleromyxedema (papular mucinosis) with dermato-neuro syndrome: A rare, potentially fatal complication

Lichen myxedematosus: a rare group of cutaneous mucinosis

“…Paraproteinemia with or without hyperviscosity might explain neurologic manifestations such as encephalopathy, seizures, cerebrovascular events, transient focal neurologic disturbances, and peripheral neuropathy observed in scleromyxedema. 13,14 Mucin deposition in the brain has not been demonstrated to be responsible for these. Peripheral neuropathy in scleromyxedema remains unclear, and carpal tunnel syndrome has been explained as a deposition of mucin within the wrist or secondary to direct median nerve toxicity.…”

SARS-CoV-2: A potential trigger of dermato-neuro syndrome in a patient with scleromyxedema

“…5,6 Enhanced blood-brain-barrier permeability in the setting of monoclonal gammopathy may elevate IgG levels in the brain microvasculature, causing hyperviscosity, sludging, and neurologic abnormalities. [7][8][9] Available literature indicates that reported cases of DNS are frequently preceded by a flu-like prodrome 3,4,[9][10][11][12][13][14][15][16][17][18] or other suspected upper respiratory tract infection. 8,19 Notably, 2 case studies identified influenza A infection in association with DNS.…”