Lichen myxedematosus: a rare group of cutaneous mucinosis

Cardenas-Gonzalez, Ramiro Eugenio; Herz‐Ruelas, Maira Elizabeth; Candiani, Jorge Ocampo

doi:10.1590/abd1806-4841.20198478

Cited by 10 publications

(12 citation statements)

References 57 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Histological findings are similar to those of discrete papular lichen myxedematous, only with more prevalent fibrosis. 9,10 This case highlights the importance of including syphilis on the differential diagnosis in a patient with an undifferentiated rash with no response to immunosuppressive agents, even when classic features of secondary syphilis are not present. The clinicopathologic consistency between our case and of previously published case reports suggests that granulomatous secondary syphilis is its own unique subtype that presents in a unique but predictable manner.…”

mentioning

confidence: 51%

Unexpected Granulomatous Dermatitis

Murray¹,

Fagan²,

Eikenberg³

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

mentioning

confidence: 51%

Unexpected Granulomatous Dermatitis

Murray¹,

Fagan²,

Eikenberg³

et al. 2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

“…Plaquelike cutaneous mucinosis is an infrequent variant of lichen myxedematosus that presents with features that are atypical or intermediate between diffuse (scleromyxedema) and localized lichen myxedematosus. 3 It is more frequent in middle-aged women and is characterized by multiple erythematous or hyperpigmented papules coalescing into well-demarcated plaques on the back, chest, or both. Histologically, it presents with a mild to moderate perivascular and perifollicular lymphocytic infiltrate and interstitial dermal mucin.…”

Section: Discussionmentioning

confidence: 99%

Improvement of plaquelike cutaneous mucinosis after intravenous immunoglobulins treatment

et al. 2020

View full text Add to dashboard Cite

“…Cutaneous mucinoses are a heterogeneous group of dermatoses characterized by the abnormal deposition of mucins in the skin. 1 Mucins are heavily glycosylated proteins, such as glycosaminoglycans. Cutaneous mucinoses can be classified into primary cutaneous mucinoses (PCM) and secondary cutaneous mucinoses (SCM).…”

Section: Introductionmentioning

confidence: 99%

Identifying the potential origin of mucin in primary cutaneous mucinoses—A retrospective study and analysis using histopathology and multiplex fluorescence staining

Steinmann

Guillet

Cheng

et al. 2023

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background: Primary cutaneous mucinoses (PCM) are rare diseases characterized by dermal or follicular mucin deposits. Objectives: A retrospective study characterizing PCM to compare dermal with follicular mucin to identify its potential origin on a single-cell level. Material and methods: Patients diagnosed with PCM between 2010 and 2020 at our department were included in this study. Biopsy specimens were stained using conventional mucin stains (Alcian blue, PAS) and MUC1 immunohistochemical staining. Multiplex fluorescence staining (MFS) was used to investigate which cells were associated with MUC1 expression in select cases. Results: Thirty-one patients with PCM were included, 14 with follicular mucinosis (FM), 8 with reticular erythematous mucinosis, 2 with scleredema, 6 with pretibial myxedema and one patient with lichen myxedematosus. In all 31 specimens, mucin stained positive for Alcian blue and negative for PAS. In FM, mucin deposition was exclusively found in hair follicles and sebaceous glands. None of the other entities showed mucin deposits in follicular epithelial structures. Using MFS, all cases showed CD4+ and CD8+ T cells, tissue histiocytes, fibroblasts and pan-cytokeratin+ cells. These cells expressed MUC1 at different intensities. MUC1 expression in tissue histiocytes, fibroblasts, CD4+ and CD8+ T cells, and follicular epithelial cells of FM was significantly higher than the same cell types in the dermal mucinoses (p < 0.001). CD8+ T cells were significantly more involved in expression of MUC1 than all other analysed cell types in FM. This finding was also significant in comparison with dermal mucinoses. Conclusion: Various cell types seem to contribute to mucin production in PCM. Using MFS, we showed that CD8+ T cells seem to be more involved in the production of mucin in FM than in dermal mucinoses, which could indicate that mucin in dermal and follicular epithelial mucinoses have different origins.

show abstract

Lichen myxedematosus: a rare group of cutaneous mucinosis

Cited by 10 publications

References 57 publications

Unexpected Granulomatous Dermatitis

Unexpected Granulomatous Dermatitis

Improvement of plaquelike cutaneous mucinosis after intravenous immunoglobulins treatment

Identifying the potential origin of mucin in primary cutaneous mucinoses—A retrospective study and analysis using histopathology and multiplex fluorescence staining

Contact Info

Product

Resources

About