Scleroderma and carcinoma of the lung

Twersky, Jack; Twersky, Naomi; Lehr, Cynthia

doi:10.1016/s0009-9260(76)80147-x

Cited by 16 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased risk of developing lung cancer was confirmed in our study. Possible mechanisms [19][20][21] In the current study, the mean age at lung cancer diagnosis was 54 years, which is similar to the age reported by Topuzoglu, 23 and much earlier than that of the general population (65-69 years). 24 In all patients the lung cancer had developed after SSc onset, indicating a potential association between existing SSc and subsequent lung cancer development.…”

Section: Discussionsupporting

confidence: 87%

“…The increased risk of developing lung cancer was confirmed in our study. Possible mechanisms [19][20][21] are the following: First, abnormal immune processes possibly associated with tumour development, epithelial cells of the terminal bronchia have an inherent potential for proliferation-thus, they have the potential for malignant transformation. Second, DNA damage caused by reactive oxygen of which the elevated level was confirmed in SSc patients and was associated with ILD may contributes to tumour genesis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Risk and prognosis factors for systemic sclerosis with lung cancer: A single‐centre case‐control study in China

et al. 2020

View full text Add to dashboard Cite

Objective To analyse clinical characteristics, risk and prognosis factors for systemic sclerosis (SSc) patients with lung cancer. Methods SSc patients with lung cancer admitted to Peking Union Medical College Hospital from February 1992 to December 2018 were included. Age and sex‐matched controls were selected from a pool of SSc patients without lung cancer during the same period. Conditional logistic regression and Cox proportional‐hazard regression were used to identify risk factors and prognosis factors. The Kaplan‐Meier method was used to draw the survival curve and calculate median survival. Results Nineteen SSc patients with lung cancer and 76 controls were included. The mean age at lung cancer diagnosis was 54.4 ± 10.2 years. In all 19 cases the lung cancer had been diagnosed after SSc and the median interval between SSc onset and lung cancer onset was 10.5 years (range 2.0‐36.2 years). Among SSc patients with lung cancer, the median follow‐up time and median survival were 2.6 years and 1.4 years, respectively. In the sex and age‐matched conditional logistic multivariable regression analysis, family history of malignancy (OR 4.930, 95%CI 1.926‐12.619, P = .001), ILD (OR 7.701, 95%CI 1.009‐58.767, P = .049) were independent risk factors for lung cancer among SSc patients, and considering sex and age of SSc onset, SSc patients with more advanced staging of lung cancer (HR 3.190, 95%CI 1.127‐6.126, P = .06) had poorer prognosis. Conclusion Lung cancer is not uncommon in SSc patients, especially those with family histories of malignancy or ILD. Early detection of lung cancer is of vital importance for better prognosis.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Risk and prognosis factors for systemic sclerosis with lung cancer: A single‐centre case‐control study in China

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Third, DNA damage induced by reactive oxygen species (ROS) might initiate malignant transformation [ 1 ], although there is no report demonstrating direct evidence for this. Fourth, reduced clearance of carcinogens in the area of ILD may be causative or the atypical epithelium may be susceptible to carcinogens [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Lung Cancer Associated With Systemic Sclerosis

et al. 2015

View full text Add to dashboard Cite

We here describe a 50-year-old woman diagnosed with squamous cell lung cancer (SqLC) with underlying interstitial lung disease (ILD) 14 years after a diagnosis of systemic sclerosis (SSc). We reviewed the literature and collected 21 well-documented cases with SqLC associated with SSc including the present case. Several characteristics of SqLC associated with SSc have been found. First, the average age at diagnosis of SqLC is 57 years, which is much younger than that reported for patients without SSc. Second, SqLC could occur even in never or light smokers, although SqLC usually has a strong association with smoking history. Third, two-thirds of the available cases have ILD. In addition, SqLC developed in the area of ILD in most cases with ILD. Fourth, SqLC generally occurs after a long period from the diagnosis of SSc; the average of this interval reaches 12 years. It would be helpful to know these features so that physicians follow up and treat SSc patients adequately.

show abstract

“…This type of lung tumour may be superimposed on any type of inflammatory interstitial pulmonary disease (Twersky et al, 1976).…”

Section: Discussionmentioning

confidence: 99%