Rapidly progressive scleroderma associated with carcinoma of the oesophagus.

Mattingly, P. C.; Mowat, A G

doi:10.1136/ard.38.2.177

Cited by 13 publications

(4 citation statements)

References 6 publications

(5 reference statements)

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“…Isolated case reports suggest a higher incidence of bronchoalveolar type of lung carcinoma (15)(16)(17); however, none of the epidemiologic studies have confirmed that (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Other types of cancers reportedly more common in scleroderma patients include breast cancer (1,5,6,10,(18)(19)(20)(21), nonmelanoma skin cancer (3), non-Hodgkin's lymphoma (1,22,23), esophageal cancer (24)(25)(26), and liver cancer (3).…”

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confidence: 99%

Risk of malignancy in scleroderma: A population‐based cohort study

Chatterjee¹,

Dombi²,

Severson³

et al. 2005

Arthritis & Rheumatism

115

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Objective. To determine the incidence of cancer in patients with scleroderma (systemic sclerosis) and to compare those rates with cancer rates in the local population.Methods. Cancer risk in scleroderma patients in the Detroit metropolitan area was assessed by linking patient identification codes of the Michigan Scleroderma Registry to the Metropolitan Detroit Cancer Surveillance System database. Patients were screened between the years 1973 and 2002, with additional followup to 2004. Standardized incidence ratios (SIRs) were calculated for selected malignancies (lung, liver, colon, breast, cervical, and prostate cancers, and nonHodgkin's lymphomas), with stratification by sex and race.Results. Of 934 patients in the Scleroderma Registry, 538 were included in the study based on tri-county residency (436 females and 102 males). Of these, 45 first malignancies were noted (37 females and 8 males). Lung cancer (10 cases) was found to be the most common cancer in scleroderma patients. However, its incidence was not significantly different from that in the general population of metropolitan Detroit (SIR 1.23). Other types of cancer were examined, and no significant differences were found as compared with the rates in the local population, with 1 exception: black females with scleroderma had significantly higher rates of liver cancer (SIR 45.8).Conclusion. Contrary to previous studies, this study did not find statistical evidence of an increased incidence of cancer in scleroderma patients, except for liver cancer. One possible reason is the high background rates of certain cancers in the metropolitan Detroit area. It may be necessary to consider local cancer rates when comparing different scleroderma cohorts.

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confidence: 99%

Risk of malignancy in scleroderma: A population‐based cohort study

Chatterjee¹,

Dombi²,

Severson³

et al. 2005

Arthritis & Rheumatism

115

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“…The most frequent types of malignancy associated with PSS are carcinoma of the breast and lung 7–10 . Nevertheless, PSS has been suspected to be related to some other types of neoplasms, such as carcinoma of the ovary, 11 oesophagus, 12 colon and rectum, 13,14 lympho‐ma, 6 and multiple myeloma 14 . Talbott and Barrocas 14,15 noted that 77% of the reported lung cancers in patients with PSS were adenocarcinoma and bronchoalveolar cell carcinomas, which were known to occur in scarred and fibrotic lung tissue.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Skin Associated with Systemic Sclerosis

Öztürk

Benekli

Altundag

et al. 1998

Dermatologic Surgery

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“…There are isolated case reports of scleroderma associated with other malignancies, the best documented instances being those of alveolar and bronchiolar cell carcinoma of the lung, 7,8 and stomach, 9 functioning carcinoid tumour 10 and more recently carcinoma of the oesophagus 11,12 . In none of these is there any real understanding of the pathogenesis, although hormonal, immunological, enzymatic and toxic mechanisms have been suggested.…”

Section: Discussionmentioning

confidence: 99%