Scleroderma After Cosmetic Surgery

Abstract

In 9 cases of human adjuvant disease, 4 cases of scleroderma (3 progressive systemic sclerosis and 1 localized morphea) were observed. Seven to 19 years after injection of foreign substances into the breasts or nose for cosmetic purposes, some patients developed human adjuvant disease. In one case the foreign substances were removed by bilateral mastectomy with no discernible effects on the patient's clinical course. Histopathologic findings of the removed breasts demonstrated foreign body granulomas with calcification. The injected substance was identified as a mixture of liquid and solid paraffin. Human adjuvant disease might be caused by prolonged hypersensitization activated by the injected foreign materials which act as an adjuvant.

A Pediatric Case of Sclerodermatous Chronic Graft‐versus‐Host Disease

“…Differentiation is required among diseases with scleroderma‐like symptoms, including paraneoplastic dermal lesions, mucinosis, metabolic abnormalities, connective tissue disease, and lesions caused by extrinsic factors such as silicone (1), tryptophan (2), vinyl chloride (3), toxic oil (4), and bleomycin (5). Sclerodermatous dermal lesions accompanying chronic GVHD were diagnosed based on the onset subsequent to bone marrow transplant, the lack of malignant tumors or prior history of exposure to chemical substances, and the absence of mucin deposition noted in histopathologic studies.…”

Urinary Tract Prostheses and their Biocompatibility

“…The association between subcutaneous injection of foreign substances and a condition indicative of an autoimmune disease was recognised and termed "human adjuvant disease" by Miyoshi et al in 1964. Several definitive connective tissue diseases have been identified in patients after the injection of subcutaneous silicone, including scleroderma (Kumagai et al, 1979), rheumatoid arthritis, Sjogren's syndrome and Hashimoto's thyroiditis. In 1982 Van Nunen et al were the first to describe an autoimmune syndrome following breast augmentation with a gel-filled prosthesis and similar reports have followed (Baldwin and Kaplan, 1983).…”

Sclerosing lipogranuloma of the male genitalia: ultrastructural study

“…No evidence for ruptured dermoid cysts and subsequent reaction to endogenous lipids was noted in our case. The clinical and histological aspects were also different from those of localized scleroderma (Kumagai et al^ 1979). No calcium deposits were seen (paraffin and silicone do not undergo calcification themselves-Wren & Crosbie, 1968).…”

“…It seems now admissible to define this entity after Oertel and Jolnson's interpretation as 'a local reactive process following injeaion of exogenous lipids into the subcutaneous tissues'. The discovery of paraffin hydrocarbons by infrared spectrophotometry in such cases ruled out the possibility that these lesions might be interpreted as a response to the degradation of endogenous lipids (Kumagai, Abe & Shiokawa, 1979;Oertel & Johnson, 1977). No evidence for ruptured dermoid cysts and subsequent reaction to endogenous lipids was noted in our case.…”