Scleroderma (Acrosclerosis)

Rukavina, John G.; Mendelson, Charles; Price, J. M.; Brown, R. R.; Johnson, Sture A. M.

doi:10.1038/jid.1957.101

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1959

1982

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Cited by 15 publications

(2 citation statements)

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“…probably via nucleic acid dependent processes (3). Whether low or high concentrations of zinc inter fere with the e�tablishment of intramolecular cross linking by means of the copper-containing enzyme lysyl oxidase is still a matter of contention (8).…”

Section: Discussionmentioning

confidence: 99%

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65Zinc absorption in untreated and D-penicillamine-treated patients with generalized scleroderma: determination by whole-body counting technique

Høyer,

Hvid-Jacobsen,

Weismann

1982

Acta Derm Venereol

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65Zinc absorption in patients suffering from generalized scleroderma was studied by means of whole-body counting technique following a single dose of 65Zn. In 4 untreated patients the mean 65Zn absorption was calculated to 35% (range 20-59%). Five patients receiving oral D-penicillamine had a numerically higher mean absorption value of 55% (range 37-74%). The results corroborate earlier studies on the effect of D-penicillamine on 65Zn absorption in rats.

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Section: Discussionmentioning

confidence: 99%

“…In 1957 Rukavina (8) suggested that the abnorma) collagen metaboli'>m in generalized sclerodcrma (GS) might be due to lack of or excess of certain trace element� or, alternatively, depcnd on changes in metallo-en1yme function following chelation. De tails of such hypothetical mcchani<,ms remain un clarified.…”

mentioning

confidence: 99%