1960
DOI: 10.1001/archderm.1960.01580050074009
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Edathamil in the Treatment of Scleroderma and Calcinosis Cutis

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Cited by 17 publications
(5 citation statements)
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“…(de Groot 1986). Winder and Curtis (1960) treated 19 patients for acrosclerosis with IV Disodium EDTA given over a 4-to 6-hour period. A majority of the patients received 2.5 to 3.0 g of Disodium EDTA in 500 cc 5% dextrose and water for 15 days.…”
Section: Case Reportsmentioning
confidence: 99%
“…(de Groot 1986). Winder and Curtis (1960) treated 19 patients for acrosclerosis with IV Disodium EDTA given over a 4-to 6-hour period. A majority of the patients received 2.5 to 3.0 g of Disodium EDTA in 500 cc 5% dextrose and water for 15 days.…”
Section: Case Reportsmentioning
confidence: 99%
“…Edathamil has been used to treat calcinosis with success. 2 adrenal steroids in calcinosis in a patient with scleroderma. Robertson et al 5 reported the efficacy of low-dose minocycline to control calcinosis in systemic sclerosis in 9 patients with limited systemic sclerosis, reducing the size of calcinosis deposits and decreasing the frequency of ulceration and inflammation associated with calcinosis.…”
Section: Discussionmentioning
confidence: 98%
“…The number of isolated cases reported that were treated empirically and no organized trial has highlighted the absence of an effective and codified treatment for CC. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] The following agents have been prescribed: diltiazem, 11 aluminum hydroxide, 12 sodium thiosulfate, 13 colchicine, 14 edathamil, 15 intravenous immunoglobulins, 16 carbon-dioxide laser, 17 warfarin, 18 minocycline, 19 or bisphosphonates, 20-23 achieving variable efficacy and causing significant side effects. Excision of CC that are painful or a source of disability is sometimes proposed, but the topography (distal and periarticular site for SSC) and the extent of the lesions (CVI) can render surgical management difficult.…”
Section: Discussionmentioning
confidence: 99%