Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA

Abstract

EDTA (ethylenediamine tetraacetic acid) and its salts are substituted diamines. HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt are substituted amines. These ingredients function as chelating agents in cosmetic formulations. The typical concentration of use of EDTA is less than 2%, with the other salts in current use at even lower concentrations. The lowest dose reported to cause a toxic effect in animals was 750 mg/kg/day. These chelating agents are cytotoxic and weakly genotoxic, but not carcinogenic. Oral exposures to EDTA produced adverse reproductive and developmental effects in animals. Clinical tests reported no absorption of an EDTA salt through the skin. These ingredients are likely, however, to affect the passage of other chemicals into the skin because they will chelate calcium. Exposure to EDTA in most cosmetic formulations, therefore, would produce systemic exposure levels well below those seen to be toxic in oral dosing studies. Exposure to EDTA in cosmetic formulations that may be inhaled, however, was a concern. An exposure assessment done using conservative assumptions predicted that the maximum EDTA dose via inhalation of an aerosolized cosmetic formulation is below that shown to produce reproductive or developmental toxicity. Because of the potential to increase the penetration of other chemicals, formulators should continue to be aware of this when combining these ingredients with ingredients that previously have been determined to be safe, primarily because they were not significantly absorbed. Based on the available data, the Cosmetic Ingredient Review Expert Panel found that these ingredients are safe as used in cosmetic formulations.

Cooking with EDTA reduces nutritional value of Vicia faba beans

“…Online with the previous statements, our results showed that a significant decrease in the Ca and Mg levels and a significant increase in Na levels in seed coats upon boiling with EDTA. This result was in agreement with other studies reported that soaking by using EDTA accelerated the cooking process of V. faba beans [12]. Having these facts, the chelation properties of EDTA may affect the mineral contents in beans that in turn decreased their nutritional value.…”

“…EDTA was also used as an antimicrobial agent for wound care [10] and intraocular lens implantation [11]. The lowest reported toxic dose of EDTA was found to be 750 mg/kg/day [12]. EDTA addition to food products widely accepted due to the high safety margin renders.…”

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

“…Gram negative nosocomial pathogen Pseudomonas aeruginosa causes a variety of infections including spontaneous bacterial peritonitis pyogenic liver abscess, sepsis and septic shock [1], [2], [3]. Endotoxin, which is a hydrophobic glycolipid, is known to play a very imperative role in pathogenesis of P. aeruginosa mediated infections [4], [5], [6].…”

Novel chelant‐based washing method for soil contaminated with Pb and other metals: A pilot‐scale study

“…EDTA is characterized by low levels of biodegradability and high levels of environmental persistence (Bloem, Haneklaus, Haensch, & Schnug, 2017). At environmental concentrations, it is relatively harmless to humans (Lanigan & Yamarik, 2002), and a concentration of 2,200 μg EDTA L −1 has been determined to have no effects in water (European Chemicals Bureau, 2004).…”