2002
DOI: 10.1080/10915810290096522
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Final Report on the Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA

Abstract: EDTA (ethylenediamine tetraacetic acid) and its salts are substituted diamines. HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt are substituted amines. These ingredients function as chelating agents in cosmetic formulations. The typical concentration of use of EDTA is less than 2%, with the other salts in current use at even lower concentrations. The lowest dose reported to cause a toxic effect in animals was 750 mg/kg/day. These chelating agents are cytotoxic and weakly genotoxic, b… Show more

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Cited by 102 publications
(27 citation statements)
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“…Online with the previous statements, our results showed that a significant decrease in the Ca and Mg levels and a significant increase in Na levels in seed coats upon boiling with EDTA. This result was in agreement with other studies reported that soaking by using EDTA accelerated the cooking process of V. faba beans [12]. Having these facts, the chelation properties of EDTA may affect the mineral contents in beans that in turn decreased their nutritional value.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Online with the previous statements, our results showed that a significant decrease in the Ca and Mg levels and a significant increase in Na levels in seed coats upon boiling with EDTA. This result was in agreement with other studies reported that soaking by using EDTA accelerated the cooking process of V. faba beans [12]. Having these facts, the chelation properties of EDTA may affect the mineral contents in beans that in turn decreased their nutritional value.…”
Section: Discussionsupporting
confidence: 93%
“…EDTA was also used as an antimicrobial agent for wound care [10] and intraocular lens implantation [11]. The lowest reported toxic dose of EDTA was found to be 750 mg/kg/day [12]. EDTA addition to food products widely accepted due to the high safety margin renders.…”
Section: Introductionmentioning
confidence: 99%
“…Gram negative nosocomial pathogen Pseudomonas aeruginosa causes a variety of infections including spontaneous bacterial peritonitis pyogenic liver abscess, sepsis and septic shock [1], [2], [3]. Endotoxin, which is a hydrophobic glycolipid, is known to play a very imperative role in pathogenesis of P. aeruginosa mediated infections [4], [5], [6].…”
Section: Introductionmentioning
confidence: 99%
“…EDTA is characterized by low levels of biodegradability and high levels of environmental persistence (Bloem, Haneklaus, Haensch, & Schnug, 2017). At environmental concentrations, it is relatively harmless to humans (Lanigan & Yamarik, 2002), and a concentration of 2,200 μg EDTA L −1 has been determined to have no effects in water (European Chemicals Bureau, 2004).…”
Section: Introductionmentioning
confidence: 99%