Scintigraphy using a technetium 99m‐labelled anti‐E‐selectin Fab fragment in rheumatoid arthritis

Abstract

(99m)Tc-anti-E-selectin-Fab scintigraphy can be used successfully to image synovitis with better specificity than (99m)Tc-HDP bone scanning. The advantages over (111)In-1.2B6-F(ab')(2) are easier availability of the radionuclide, improved physical properties and optimal imaging 4 h after injection.

Ethanol affects the absorption and tissue distribution of orally administered antigens in mice

“…An earlier study has demonstrated a decrease in the level of IgA antibodies against palmitoyl-ova in the intestinal fluid from ethanol-treated mice; however, systemic immunological events induced by orally administered antigens were not affected (Gusmão et al 2004). In this study, 99m Tc, a radionuclide widely used to label the drugs, peptides and antibodies was used for biodistribution studies (Jamar et al 2002). Free 99m Tc accumulates largely in the thyroid and stomach wall (Argonne National Laboratory 2005).…”

Evaluation of a 3-Hour Indium-111 Leukocyte Image as a Surrogate for a Technetium-99m Nanocolloid Marrow Scan in the Diagnosis of Orthopedic Infection

“…Several new agents for imaging inflammation that have been reported recently are not associated with the problem of simultaneous uptake in bone marrow, such as radiolabeled anti-E-selectin, 20,21 Tc-99m-labeled ciprofloxacin, 22 Tc-99m sulesomab 23,24 and other antigranulocyte antibodies, 25 polyclonal human immunoglobulin, 26 and Tc-99m-labeled interleukin-8. 27 Nevertheless, leukocyte scintigraphy remains the gold standard, and so attempts to consolidate its diagnostic accuracy are worthwhile.…”

The Development of Targeted Drug Delivery Systems for Rheumatoid Arthritis Treatment

“…Angiogenic vascular endothelial cells (VECs) are also present as a result of neovascularization, and the E-selectin adhesion molecule has been identified as another viable target for drug delivery (Jamar et al, 2002).…”